| Autor: |
Inácio CR; Department of Chemistry, Federal University of Ouro Preto, Ouro Preto 35400-000, MG, Brazil., Nascimento GS; Department of Chemistry, Federal University of Ouro Preto, Ouro Preto 35400-000, MG, Brazil., Barboza APM; Department of Physics, Federal University of Ouro Preto, Ouro Preto 35400-000, MG, Brazil., Neves BRA; Department of Physics, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, Brazil., Andrade ÂL; Department of Chemistry, Federal University of Ouro Preto, Ouro Preto 35400-000, MG, Brazil., Teixeira GM; Center for Research in Biological Sciences, Laboratory of Morphopathology, Federal University of Ouro Preto, Ouro Preto 35400-000, MG, Brazil., Sousa LRD; Center for Research in Biological Sciences, Laboratory of Morphopathology, Federal University of Ouro Preto, Ouro Preto 35400-000, MG, Brazil., de A Vieira PM; Center for Research in Biological Sciences, Laboratory of Morphopathology, Federal University of Ouro Preto, Ouro Preto 35400-000, MG, Brazil., Novack KM; Department of Chemistry, Federal University of Ouro Preto, Ouro Preto 35400-000, MG, Brazil., Dos Santos VMR; Department of Chemistry, Federal University of Ouro Preto, Ouro Preto 35400-000, MG, Brazil. |
| Abstrakt: |
In recent years, polymeric materials have been gaining prominence in studies of controlled release systems to obtain improvements in drug administration. These systems present several advantages compared with conventional release systems, such as constant maintenance in the blood concentration of a given drug, greater bioavailability, reduction of adverse effects, and fewer dosages required, thus providing a higher patient compliance to treatment. Given the above, the present work aimed to synthesize polymeric matrices derived from polyethylene glycol (PEG) capable of promoting the controlled release of the drug ketoconazole in order to minimize its adverse effects. PEG 4000 is a widely used polymer due to its excellent properties such as hydrophilicity, biocompatibility, and non-toxic effects. In this work, PEG 4000 and derivatives were incorporated with ketoconazole. The morphology of polymeric films was observed by AFM and showed changes on the film organization after drug incorporation. In SEM, it was possible to notice spheres that formed in some incorporated polymers. The zeta potential of PEG 4000 and its derivatives was determined and suggested that the microparticle surfaces showed a low electrostatic charge. Regarding the controlled release, all the incorporated polymers obtained a controlled release profile at pH 7.3. The release kinetics of ketoconazole in the samples of PEG 4000 and its derivatives followed first order for PEG 4000 HYDR INCORP and Higuchi for the other samples. Cytotoxicity was determined and PEG 4000 and its derivatives were not cytotoxic. |
