Clinical Profile and Determinants of Mortality in Patients with Interstitial Lung Disease Admitted for COVID-19.

Autor: Mulet A; Pulmonary Department, Hospital Clínico Universitario Valencia, INCLIVA, 46010 Valencia, Spain., Núñez-Gil IJ; Cardiology Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), 28040 Madrid, Spain., Carbonell JA; Bioinformatics and Biostatistics Unit, INCLIVA, 46010 Valencia, Spain., Soriano JB; Faculty of Medicine, Universitat de les Illes Balears, 07120 Palma, Spain.; Centro de Investigación en Red de Enfermedades Respiratorias, Instituto de Salud Carlos III, 28029 Madrid, Spain., Viana-Llamas MC; Intensive Medicine Department, Hospital Universitario Guadalajara, 19002 Guadalajara, Spain., Raposeiras-Roubin S; National Center for Cardiovascular Research (CNIC), Department of Cardiology, Álvaro Cunqueiro University Hospital, 36312 Vigo, Spain., Romero R; Emergency Department, Hospital Universitario Getafe, 28905 Madrid, Spain., Alfonso-Rodríguez E; Bellvitge University Hospital, 08907 Barcelona, Spain., Uribarri A; Cardiology Department, Hospital Clínico Universitario Vall D'Hebrón, 08035 Barcelona, Spain., Feltes G; Cardiology Department, Hospital Universitario Vithas Arturo Soria, 28043 Madrid, Spain., Becerra-Muñoz VM; Cardiology Department, Hospital Clínico Universitario Virgen de la Victoria, 29010 Malaga, Spain., Santoro F; Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy., Pepe M; Cardiology Department, Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari, 70124 Bari, Italy., Castro-Mejía AF; Hospital General del Norte de Guayaquil IESS Los Ceibos, Guayaquil 090615, Ecuador., Chipayo D; Department of Cardiology, Hospital Universitario de Cáceres, 10004 Cáceres, Spain., Corbi-Pascual M; Department of Cardiology, Complejo Hospitalario Universitario de Albacete, 02008 Albacete, Spain., López-Pais J; Department of Cardiology, Complejo Hospitalario Universitario de Ourense, 32005 Ourense, Spain., Vedia O; Instituto de Investigación, Sanitaria del Hospital Clínico San Carlos (IdISSC), Hospital Clínico San Carlos, Universidad Complutense de Madrid, 28040 Madrid, Spain., Manzone E; Hospital del Sureste, 28500 Madrid, Spain., Molina-Romera G; Department of Preventive Medicine, Hospital Santiago de Compostela, Instituto de Investigaciones Sanitarias de Santiago de Compostela, 15706 A Coruña, Spain., Espejo-Paeres C; Hospital Príncipe Asturias, 28805 Alcalá de Henares, Spain., López-Masjuan Á; Department of Cardiology, Hospital Universitario Juan Ramon Jimenez, 21005 Huelva, Spain., Velicki L; Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia.; Institute of Cardiovascular Diseases Vojvodina, 21204 Sremska Kamenica, Serbia., Fernández-Ortiz A; Cardiology Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), 28040 Madrid, Spain., El-Battrawy I; Department of Cardiology, University Medical Center Mannheim, 68167 Mannheim, Germany., Signes-Costa J; Pulmonary Department, Hospital Clínico Universitario Valencia, INCLIVA, 46010 Valencia, Spain., On Behalf Of Hope Team
Jazyk: angličtina
Zdroj: Journal of clinical medicine [J Clin Med] 2023 Jun 02; Vol. 12 (11). Date of Electronic Publication: 2023 Jun 02.
DOI: 10.3390/jcm12113821
Abstrakt: Background: Concern has risen about the effects of COVID-19 in interstitial lung disease (ILD) patients. The aim of our study was to determine clinical characteristics and prognostic factors of ILD patients admitted for COVID-19.
Methods: Ancillary analysis of an international, multicenter COVID-19 registry (HOPE: Health Outcome Predictive Evaluation) was performed. The subgroup of ILD patients was selected and compared with the rest of the cohort.
Results: A total of 114 patients with ILDs were evaluated. Mean ± SD age was 72.4 ± 13.6 years, and 65.8% were men. ILD patients were older, had more comorbidities, received more home oxygen therapy and more frequently had respiratory failure upon admission than non-ILD patients (all p < 0.05). In laboratory findings, ILD patients more frequently had elevated LDH, C-reactive protein, and D-dimer levels (all p < 0.05). A multivariate analysis showed that chronic kidney disease and respiratory insufficiency on admission were predictors of ventilatory support, and that older age, kidney disease and elevated LDH were predictors of death.
Conclusions: Our data show that ILD patients admitted for COVID-19 are older, have more comorbidities, more frequently require ventilatory support and have higher mortality than those without ILDs. Older age, kidney disease and LDH were independent predictors of mortality in this population.
Databáze: MEDLINE
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