Helicobacter pylori Infection and Peptic Ulcer Disease in Symptomatic Children in Southern Vietnam: A Prospective Multicenter Study.

Autor:	Nguyen TC; Department of Gastroenterology, City Children's Hospital, Ho Chi Minh City 700000, Vietnam.; Faculty of Medicine, Université Libre de Bruxelles, 1020 Brussels, Belgium., Tang NLC; Department of Gastroenterology, Children's Hospital 2, Ho Chi Minh City 700000, Vietnam., Le GKN; Department of Microbiology and Parasitology, University of Medicine and Pharmacy, Ho Chi Minh City 700000, Vietnam., Nguyen VT; Department of Genetics, University of Science-Vietnam National University Ho Chi Minh City, Ho Chi Minh City 700000, Vietnam., Nguyen KHG; Department of Biostatistics and Informatics, Pham Ngoc Thach University of Medicine, Ho Chi Minh City 700000, Vietnam., Che TH; Department of Biostatistics and Informatics, Pham Ngoc Thach University of Medicine, Ho Chi Minh City 700000, Vietnam., Phan VTT; Department of Gastroenterology, City Children's Hospital, Ho Chi Minh City 700000, Vietnam., Nguyen NM; Department of Gastroenterology, Children's Hospital 2, Ho Chi Minh City 700000, Vietnam., Truong DQ; Department of Surgery, City Children's Hospital, Ho Chi Minh City 700000, Vietnam., Ngo XM; Faculty of Medicine, Pham Ngoc Thach University of Medicine, Ho Chi Minh City 700000, Vietnam., Nguyen HT; Faculty of Public Health, Pham Ngoc Thach University of Medicine, Ho Chi Minh City 700000, Vietnam., Robert A; Institut de Recherche Expérimentale et Clinique, Pôle d'Épidémiologie et Biostatistique, Université Catholique de Louvain, 1200 Brussels, Belgium., Bontems P; Faculty of Medicine, Université Libre de Bruxelles, 1020 Brussels, Belgium.; Department of Gastroenterology, Hôpital Universitaire des Enfants Reine Fabiola, 1020 Brussels, Belgium., Nguyen PNV; Department of Biostatistics and Informatics, Pham Ngoc Thach University of Medicine, Ho Chi Minh City 700000, Vietnam.
Jazyk:	angličtina
Zdroj:	Healthcare (Basel, Switzerland) [Healthcare (Basel)] 2023 Jun 05; Vol. 11 (11). Date of Electronic Publication: 2023 Jun 05.
DOI:	10.3390/healthcare11111658
Abstrakt:	Background: Helicobacter pylori ( H. pylori ) remains a major cause of gastroduodenal diseases. We aimed to evaluate the burden of this infection, particularly peptic ulcer disease in Vietnamese children. Methods: We enrolled consecutive children referred for esophagogastroduodenoscopy at two tertiary children's hospitals in Ho Chi Minh City, from October 2019 to May 2021. Children treated with proton pump inhibitors during the last two weeks or antibiotics for four weeks, and those having a previous or interventional endoscopy were excluded. H. pylori infection was diagnosed with either a positive culture or positive histopathology combined with a rapid urease test, or with a polymerase chain reaction of the urease gene. The study was approved by the Ethics Committee and written informed consent/assent was obtained. Results: Among 336 enrolled children aged 4-16 (mean: 9.1 ± 2.4 years; 55.4% girls), H. pylori infection was positive in 80%. Peptic ulcers were detected in 65 (19%), increasing with age, and 25% with anemia. cagA+ strains were detected at a higher rate in children with ulcers. Conclusions: Prevalence of H. pylori and peptic ulcers is high among symptomatic Vietnamese children. It is crucial to have a program for early detection of H. pylori to reduce ulcer risk and gastric cancer later.
Databáze:	MEDLINE
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