Incidence Trends and Main Features of Gastro-Intestinal Stromal Tumours in a Mediterranean Region: A Population-Based Study.

Autor: Vaamonde-Martín RJ; Service of Epidemiology, Region of Murcia Health Council, Ronda de Levante 11, 30008 Murcia, Spain.; Institute for Biomedical Research of Murcia, IMIB-Arrixaca, 30120 Murcia, Spain., Ballesta-Ruiz M; Service of Epidemiology, Region of Murcia Health Council, Ronda de Levante 11, 30008 Murcia, Spain.; Institute for Biomedical Research of Murcia, IMIB-Arrixaca, 30120 Murcia, Spain.; School of Medicine, University of Murcia, 30100 Murcia, Spain., Sánchez-Gil A; Service of Epidemiology, Region of Murcia Health Council, Ronda de Levante 11, 30008 Murcia, Spain.; SMS (Region of Murcia Health Service) Calle Central, 7, 30100 Murcia, Spain., Fernández JÁ; School of Medicine, University of Murcia, 30100 Murcia, Spain.; University Hospital 'Virgen de la Arrixaca', 30120 Murcia, Spain., Martínez-Barba E; School of Medicine, University of Murcia, 30100 Murcia, Spain.; University Hospital 'Virgen de la Arrixaca', 30120 Murcia, Spain., Martínez-García J; University Hospital 'Virgen de la Arrixaca', 30120 Murcia, Spain., Gatta G; Evaluative Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, 20131 Milan, Italy., Chirlaque-López MD; Service of Epidemiology, Region of Murcia Health Council, Ronda de Levante 11, 30008 Murcia, Spain.; Institute for Biomedical Research of Murcia, IMIB-Arrixaca, 30120 Murcia, Spain.; School of Medicine, University of Murcia, 30100 Murcia, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain.
Jazyk: angličtina
Zdroj: Cancers [Cancers (Basel)] 2023 May 30; Vol. 15 (11). Date of Electronic Publication: 2023 May 30.
DOI: 10.3390/cancers15112994
Abstrakt: Gastro-Intestinal Stromal Tumours (GISTs) are a kind of neoplasm whose diagnosis in common clinical practice just started in the current century, implying difficulties for proper registration. Staff from the Cancer Registry of Murcia, in southeastern Spain, were commissioned by the EU Joint Action on Rare Cancers into a pilot study addressing GIST registration that also yielded a population-based depiction of GISTs in the region, including survival figures. We examined reports from 2001 to 2015 from hospitals as well as cases already present in the registry. The variables collected were sex, date of diagnosis, age, vital status, primary location, presence of metastases, and risk level according to Joensuu's Classification. In total, 171 cases were found, 54.4% occurred in males, and the mean age value was 65.0 years. The most affected organ was the stomach, with 52.6% of cases. Risk level was determined as "High" for 45.0%, with an increment of lower levels in recent years. Incidence for the year 2015 doubled that of 2001. Overall, the 5-year net survival estimation was 77.0%. The rising incidence magnitude is consistent with trends in other European countries. Survival evolution lacked statistical significance. A more interventional approach in clinical management could explain the increase in the proportion of "Low Risk GISTs" and the first occurrence of "Very Low Risk" in recent years.
Competing Interests: The authors declare no conflict of interest.
Databáze: MEDLINE
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