Association Between Sleep Time and Pro- and Anti-Inflammatory Biomarkers Is Mediated by Abdominal Obesity Among Adolescents.
| Autor: | De Moraes ACF; The University of Texas Health Science Center at Houston School of Public Health Austin Campus, Department of Epidemiology, Human Genetics, and Environmental Science, Michael & Susan Dell Center for Healthy Living, Austin, TX,USA.; Department of Epidemiology, Graduate Program in Public Health and Graduate Program in Epidemiology, School of Public Health, University of Sao Paulo, Sao Paulo, SP,Brazil.; YCARE (Youth/Child and cArdiovascular Risk and Environmental) Research Group, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP,Brazil., Medeiros-Oliveira VC; Department of Epidemiology, Graduate Program in Public Health and Graduate Program in Epidemiology, School of Public Health, University of Sao Paulo, Sao Paulo, SP,Brazil.; YCARE (Youth/Child and cArdiovascular Risk and Environmental) Research Group, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP,Brazil., Burford K; The University of Texas Health Science Center at Houston School of Public Health Austin Campus, Department of Epidemiology, Human Genetics, and Environmental Science, Michael & Susan Dell Center for Healthy Living, Austin, TX,USA., Schaan BD; Faculty of Medicine, Graduate Program in Cardiology and Cardiovascular Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS,Brazil.; Endocrine Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS,Brazil.; Faculty of Medicine, Graduate Program in Endocrinology, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS,Brazil., Bloch K; Instituto de Estudos em Saúde Coletiva, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ,Brazil., de Carvalho KMB; Graduate Program in Human Nutrition, Universidade de Brasília, Brazil., Cureau FV; Graduate Program in Cardiology and Cardiovascular Sciences, School of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS,Brazil., Nascimento-Ferreira MV; YCARE (Youth/Child and cArdiovascular Risk and Environmental) Research Group, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP,Brazil.; HEALth, pHYsical activity and Behavior ReseArch (HEALTHY-BRA) group, Federal University of Tocantins, Campus Miracema, Miracema, TO,Brazil. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of physical activity & health [J Phys Act Health] 2023 Jun 09; Vol. 20 (10), pp. 926-933. Date of Electronic Publication: 2023 Jun 09 (Print Publication: 2023). |
| DOI: | 10.1123/jpah.2022-0468 |
| Abstrakt: | Objectives: Movement behaviors and abdominal obesity are associated with higher inflammatory biomarkers. However, the role of waist circumference as a mediating factor is still unknown. Thus, our aims were to (1) test the associations between 24-hour movement behavior variables (physical activity, sedentary behavior, and sleep), abdominal obesity, and pro- and anti-inflammatory biomarkers; and (2) investigate whether abdominal obesity had a mediating effect between the investigated associations. Methods: This multicenter cross-sectional study included 3591 adolescents (aged 12-17 y) from 4 Brazilian cities. Waist circumference (in centimeters; at half the distance between the iliac crest and at the lower costal margin), 24-hour movement behaviors (validated questionnaire), high-sensitive C-reactive protein, and adiponectin (serum plasma) were evaluated. We used multiple mediation regression models (95% confidence interval) to determine if waist circumference mediated the association between 24-hour movement behaviors and pro- and anti-inflammatory biomarkers. Results: The results revealed that screen time and moderate to vigorous physical activity were not associated with pro- or anti-inflammatory biomarkers. However, sleep duration (in hours per day) was negatively associated with pro- (C-reactive protein, β = -0.08; 95% confidence interval, -0.38 to -0.02) and anti- (adiponectin, β = -0.31; 95% confidence interval, -2.13 to -0.12) inflammatory biomarkers. Our results also showed that waist circumference mediated the association between sleep duration and high-sensitive C-reactive protein (2.7%), and adiponectin (2.8%). Conclusion: Sleep duration was inversely associated with pro- and anti-inflammatory biomarkers, and these relations were mediated by abdominal obesity. Therefore, adolescents having healthy sleep can have implications for reducing waist circumference and inflammatory indicators. |
| Databáze: | MEDLINE |
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