Oxymatrine: A current overview of its health benefits.

Autor: Huan DQ; Faculty of Chemistry, Hanoi Pedagogical University 2 (HPU2), 32 Nguyen Van Linh, Xuanhoa, Phucyen, Vinhphuc, Viet Nam., Hop NQ; Faculty of Chemistry, Hanoi Pedagogical University 2 (HPU2), 32 Nguyen Van Linh, Xuanhoa, Phucyen, Vinhphuc, Viet Nam., Son NT; Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam. Electronic address: ntson@ich.vast.
Jazyk: angličtina
Zdroj: Fitoterapia [Fitoterapia] 2023 Jul; Vol. 168, pp. 105565. Date of Electronic Publication: 2023 Jun 07.
DOI: 10.1016/j.fitote.2023.105565
Abstrakt: Oxymatrine (OMT), was identified as a quinolizidine alkaloid, which was one of the major matrine-type alkaloids extracted from Sophora medicinal plants. Growing studies revealed that OMT has a wide range of beneficial pharmacological values, consisting of anticancer, antidiabetic, antivirus, and antiinflammtion, as well as the protective activities to the brain, liver, heart, lung, vascular, gastrointestinal, bone, kidney, and skin organs. Various in vitro and in vivo models of pharmacological actions were recorded in regard to the usage of alkaloidal OMT. Mechanisms underlying anticancer activity of this compound may have been possibly involved anti-proliferation, invasion, migration, angiogenesis, epithelial-mesenchymal transition of cells, autophagy, especially apoptotic cell deaths. OMT could reduce hyperglycemia and hyperlipemia in a high-fat diet and streptozotocin-stimulated diabetic mice by improving insulin secretion and sensitivity. OMT suppressed gastric ulcer via gastric inflammatory and oxidative inhibitions, and pro-apoptotic actions. It turns out that OMT is relatively safe for cell and animal experiments. In this study, we offer a systematic review of natural occurrence, pharmacological potentials, possible mechanisms of action, pharmacokinetics, and bioavailability. Clinical research with OMT is needed to extensively elucidate its health potential benefits.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023. Published by Elsevier B.V.)
Databáze: MEDLINE
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