Ancient complexes of iron and sulfur modulate oncogenes and oncometabolism.

Autor: Nghi HT; Institute of Pharmaceutical Science, School of Cancer & Pharmaceutical Sciences, King's College London, London, United Kingdom., Shahmohammadi S; Institute of Pharmaceutical Chemistry, Interdisciplinary Excellence Center and Stereochemistry Research Group, Eötvös Loránd Research Network, Faculty of Pharmacy, University of Szeged, H-6720, Szeged, Hungary., Ebrahimi KH; Institute of Pharmaceutical Science, School of Cancer & Pharmaceutical Sciences, King's College London, London, United Kingdom. Electronic address: Kourosh.ebrahimi@kcl.ac.uk.
Jazyk: angličtina
Zdroj: Current opinion in chemical biology [Curr Opin Chem Biol] 2023 Oct; Vol. 76, pp. 102338. Date of Electronic Publication: 2023 Jun 07.
DOI: 10.1016/j.cbpa.2023.102338
Abstrakt: Inorganic complexes of iron and sulfur, that is, iron-sulfur [FeS] clusters, have played a fundamental role in life on Earth since the prebiotic period. These clusters were involved in elementary reactions leading to the emergence of life and, since then, gained function in processes, such as respiration, replication, transcription, and the immune response. We discuss how three [FeS] proteins involved in the innate immune response play a role in oncogene expression/function and oncometabolism. Our analysis highlights the importance of future research into understanding the [FeS] clusters' roles in cancer progression and proliferation. The outcomes of these studies will help identify new targets and develop new anticancer therapeutics.
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Kourosh H. Ebrahimi reports financial support was provided by The Royal Society. Kourosh H. Ebrahimi, Hoang Thao Nghi reports financial support was provided by King's College London. Hoang Thao Nghi reports financial support was provided by Vietnamese Government Scholarship. Sayeh Shahmohammadi reports financial support was provided by Hungarian Scientific Research Council.
(Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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