Influence of a concurrent exercise training program during pregnancy on the placenta mitochondrial DNA integrity and content of minerals with enzymatic relevance. The GESTAFIT project.

Autor: Aparicio VA; Department of Physiology, Institute of Nutrition and Food Technology 'José Mataix Verdú', Biomedical Research Centre, University of Granada, Spain; Sport and Health University Research Centre (iMUDS), University of Granada, Spain; Glzartea, Kirola eta Ariketa Fisikoa Ikerkuntza Taldea (GIKAFIT), Society Sports and Exercise Research Group, Department of Physical Education and Sport, Faculty of Education and Sport-Physical Activity and Sport Sciences Section, University of Basque Country (UPV/EHU), Vitoria-Gasteiz, Araba/Álava, Basque Country, Spain., Baena-García L; Department of Nursing, Faculty of Health Sciences, University of Granada, Granada, Spain; The Institute of Biomedicine Research (Instituto de Investigación Biosanitaria, ibs), Spain. Electronic address: lbaenagarcia@ugr.es., Sánchez-González C; Department of Physiology, Institute of Nutrition and Food Technology 'José Mataix Verdú', Biomedical Research Centre, University of Granada, Spain., Acosta-Manzano P; Sport and Health University Research Centre (iMUDS), University of Granada, Spain; Institute of Human Movement Science, Sport and Health, University of Graz, Austria., Varela-López A; Department of Physiology, Institute of Nutrition and Food Technology 'José Mataix Verdú', Biomedical Research Centre, University of Granada, Spain., Quiles JL; Department of Physiology, Institute of Nutrition and Food Technology 'José Mataix Verdú', Biomedical Research Centre, University of Granada, Spain.
Jazyk: angličtina
Zdroj: Placenta [Placenta] 2023 Aug; Vol. 139, pp. 19-24. Date of Electronic Publication: 2023 Jun 01.
DOI: 10.1016/j.placenta.2023.05.021
Abstrakt: Introduction: We aimed i) to investigate the effects of a concurrent (aerobic plus strength) exercise intervention during pregnancy on placental mtDNA copy number, proportion of deleted mtDNA, and on the content of some trace and ultra-trace minerals with coenzymatic relevance; ii) to explore the association of such mitochondrial markers with the concentration of these minerals.
Methods: For the present study specific aims, 47 placentas were randomly selected from women that participated in the GESTAFIT project into exercise (n = 24) or control (n = 23) groups. The exercise group followed a concurrent aerobic and strength training program, three 60-min sessions/week, from the 17th gestational week until birth. Placenta tissue was collected and processed for minerals determination by the inductively coupled plasma mass spectrometry technique. RT-PCR was used to determine placentas mtDNA copy number and ND1/ND4 deletion.
Results: After adjusting for potential confounders, the mothers who participated in the exercise program had placentas with greater mtDNA copy number (p = 0.04) and lower mtDNA deletion (p = 0.003). Placentas from mothers in the exercise group presented higher manganese content than those from the controls (0.26 ± 0.03 mg/dL vs. 0.13 ± 0.03 mg/dL, p = 0.003). Placenta manganese content was significantly associated with lower mtDNA deletions (r = -0.382) and greater mtDNA copy number (r = 0.513). Iron content was associated with higher mtDNA copy number (r = 0.393). Selenium content was associated with lower mtDNA deletion (r = -0.377) and greater mtDNA copy number (r = 0.442). Finally, zinc and magnesium content were associated with higher mtDNA copy number (r = 0.447 and r = 0.453, respectively).
Discussion: This concurrent exercise training program induced a better placental status, which might be mediated through an improvement of mitochondrial bioenergetics and antioxidative capacity.
Competing Interests: Declaration of competing interest None.
(Copyright © 2023. Published by Elsevier Ltd.)
Databáze: MEDLINE
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