The pro-inflammatory cytokine IL-Iβ alteration by deer ( Rusa unicolor ) antler extract on osteoarthritis rat model.

Autor:	Widyowati R; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Nanizar Zaman Joenoes Building, Campus C, Mulyorejo Street, Surabaya 60115, East Java, Indonesia.; Natural Products Drug Delivery and Development, Faculty of Pharmacy, Universitas Airlangga, Nanizar Zaman Joenes Building, Campus C, Mulyorejo Street, Surabaya 60115, East Java, Indonesia., Suciati S; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Nanizar Zaman Joenoes Building, Campus C, Mulyorejo Street, Surabaya 60115, East Java, Indonesia.; Natural Products Drug Delivery and Development, Faculty of Pharmacy, Universitas Airlangga, Nanizar Zaman Joenes Building, Campus C, Mulyorejo Street, Surabaya 60115, East Java, Indonesia., Hariyadi DM; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Nanizar Zaman Joenoes Building, Campus C, Mulyorejo Street, Surabaya 60115, East Java, Indonesia., Chang HI; Department of Biochemical Science and Technology, National Chiayi University, Chiayi, Taiwan., Ipg Suryawan N; Department of Animal Husbandry and Animal Health Province East Kalimantan, Indonesia., Tarigan N; Department of Animal Husbandry and Animal Health Province East Kalimantan, Indonesia., Sholikhah I; Department of Chemistry, Faculty of Sains and Technology, Universitas Airlangga, Campus C, Mulyorejo Street, Surabaya 60115, East Java, Indonesia., Ardianto C; Department of Pharmacy Practice, Faculty of Pharmacy, Universitas Airlangga, Surabaya 60115, Indonesia., Nurhan AD; Master of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Surabaya 60115, Indonesia., Sagitaras IB; Master of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Surabaya 60115, Indonesia.
Jazyk:	angličtina
Zdroj:	Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society [Saudi Pharm J] 2023 Jun; Vol. 31 (6), pp. 1109-1114. Date of Electronic Publication: 2023 Apr 05.
DOI:	10.1016/j.jsps.2023.03.022
Abstrakt:	Osteoarthritis is a disease associated with articular cartilage degradation, intra-articular area inflammation, and subchondral bone replacement. Cytokine IL-1β has a prominent function in the inflammations process that passes in the joints. The 70% ethanol extracts of deer antler (250 and 500 mg/kg BW) and glucosamine sulfate (250 kg/BW) were evaluated for four weeks in reducing cytokine IL-1β to rat model OA-induced Monosodium iodoacetate. Measurements of joint diameter in rat's knee and hyperalgesia were performed on weeks 0, 1, 2, 3, 4, 5, 6, and 7. The presence of a significant difference in the stimulation thermal latency (p = 0.00) and the resulting increase in swelling of joint diameter (p = 0.00) are evidence that MIA has successfully induced the rat modeling of OA. A significant decrease in cytokine IL-Iβ levels was shown on week 3 after MIA injection (p = 0.00). Both concentrations of deer extracts significantly reduced knee joint diameter (p = 0.00), latency thermal stimulation (p = 0.00), and cytokine IL-1β levels (p = 0.00). Based on the results, it can be concluded that the 70% ethanol extract of deer antler is a potential medicine for OA therapy. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2023 The Author(s).)
Databáze:	MEDLINE
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