Spatiotemporal variability in transmission risk of human schistosomes and animal trematodes in a seasonally desiccating East African landscape.

Autor:	Starkloff NC; Department of Biology, Emory University, Atlanta, GA 30322., Angelo T; National Institute of Medical Research Mwanza Center, Mwanza, Tanzania., Mahalila MP; National Institute of Medical Research Mwanza Center, Mwanza, Tanzania., Charles J; National Institute of Medical Research Mwanza Center, Mwanza, Tanzania., Kinung'hi S; National Institute of Medical Research Mwanza Center, Mwanza, Tanzania., Civitello DJ; Department of Biology, Emory University, Atlanta, GA 30322.
Jazyk:	angličtina
Zdroj:	BioRxiv : the preprint server for biology [bioRxiv] 2023 May 26. Date of Electronic Publication: 2023 May 26.
DOI:	10.1101/2023.05.25.542103
Abstrakt:	Different populations of hosts and parasites experience distinct seasonality in environmental factors, depending on local-scale biotic and abiotic factors. This can lead to highly heterogenous disease outcomes across host ranges. Variable seasonality characterizes urogenital schistosomiasis, a neglected tropical disease caused by parasitic trematodes ( Schistosoma haematobium ). Their intermediate hosts are aquatic Bulinus snails that are highly adapted to extreme rainfall seasonality, undergoing dormancy for up to seven months yearly. While Bulinus snails have a remarkable capacity for rebounding following dormancy, parasite survival within snails is greatly diminished. We conducted a year-round investigation of seasonal snail-schistosome dynamics in 109 ponds of variable ephemerality in Tanzania. First, we found that ponds have two synchronized peaks of schistosome infection prevalence and cercariae release, though of lower magnitude in the fully desiccating ponds than non-desiccating ponds. Second, we evaluated total yearly prevalence across a gradient of an ephemerality, finding ponds with intermediate ephemerality to have the highest infection rates. We also investigated dynamics of non-schistosome trematodes, which lacked synonymity with schistosome patterns. We found peak schistosome transmission risk at intermediate pond ephemerality, thus the impacts of anticipated increases in landscape desiccation could result in increases or decreases in transmission risk with global change. Competing Interests: Conflict of Interest The authors have no conflict of interest to declare.
Databáze:	MEDLINE
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