Helicobacter pylori attachment-blocking antibodies protect against duodenal ulcer disease.

Autor:	Bugaytsova JA; Department of Medical Biochemistry and Biophysics, Umeå University, SE90187 Umeå, Sweden.; SUMEYA, The Ukrainian-Swedish Research Center, Sumy State University, 40022 Sumy, Ukraine., Moonens K; Structural and Molecular Microbiology, VIB Department of Structural Biology, VIB, 1050 Brussels, Belgium.; Structural Biology Brussels, Vrije Universiteit Brussel, 1050 Brussels, Belgium.; Present address: Ablynx, a Sanofi Company, Technologiepark 21, 9052 Zwijnaarde, Belgium., Piddubnyi A; Department of Medical Biochemistry and Biophysics, Umeå University, SE90187 Umeå, Sweden.; SUMEYA, The Ukrainian-Swedish Research Center, Sumy State University, 40022 Sumy, Ukraine.; Department of Pathology, Medical Institute, Sumy State University, 40007 Sumy, Ukraine., Schmidt A; Department of Medical Biochemistry and Biophysics, Umeå University, SE90187 Umeå, Sweden.; Division of Clinical Immunology and Transfusion Medicine, Karolinska Institutet at Karolinska University Hospital, SE14186 Huddinge, Sweden.; Present address: Department of Medical Biosciences, Umeå University, SE90185 Umeå, Sweden., Edlund JO; Department of Medical Biochemistry and Biophysics, Umeå University, SE90187 Umeå, Sweden.; The Biochemical Imaging Center Umeå (BICU), Umeå University, SE90187 Umeå, Sweden., Lisiutin G; Department of Medical Biochemistry and Biophysics, Umeå University, SE90187 Umeå, Sweden.; Department of Microbiology, Virology and Biotechnology, Odesa Mechnikov National University, 65082 Odesa, Ukraine., Brännström K; Department of Medical Biochemistry and Biophysics, Umeå University, SE90187 Umeå, Sweden.; The Biochemical Imaging Center Umeå (BICU), Umeå University, SE90187 Umeå, Sweden.; Present address: Pfizer Worldwide R&D, BioMedicine Design, 10 555 Science Center Drive, San Diego CA, 92121 USA., Chernov YA; Department of Medical Biochemistry and Biophysics, Umeå University, SE90187 Umeå, Sweden., Thorel K; Department of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Tkachenko I; Department of Medical Biochemistry and Biophysics, Umeå University, SE90187 Umeå, Sweden.; Department of Public Health, Medical Institute, Sumy State University, 40007 Sumy, Ukraine., Sharova O; Department of Medical Biochemistry and Biophysics, Umeå University, SE90187 Umeå, Sweden.; Department of Pediatrics, Medical Institute, Sumy State University, 40018 Sumy, Ukraine., Vikhrova I; Department of Medical Biochemistry and Biophysics, Umeå University, SE90187 Umeå, Sweden.; Department of Pediatrics, Medical Institute, Sumy State University, 40018 Sumy, Ukraine., Butsyk A; Department of Medical Biochemistry and Biophysics, Umeå University, SE90187 Umeå, Sweden.; Department of Public Health, Medical Institute, Sumy State University, 40007 Sumy, Ukraine., Shubin P; Department of Medical Biochemistry and Biophysics, Umeå University, SE90187 Umeå, Sweden.; Department of Public Health, Medical Institute, Sumy State University, 40007 Sumy, Ukraine., Chyzhma R; Department of Medical Biochemistry and Biophysics, Umeå University, SE90187 Umeå, Sweden.; SUMEYA, The Ukrainian-Swedish Research Center, Sumy State University, 40022 Sumy, Ukraine.; Department of Pathology, Medical Institute, Sumy State University, 40007 Sumy, Ukraine., Johansson DX; Department of Clinical Neuroscience, Karolinska Institutet at Center for Molecular Medicine, Karolinska University Hospital, Solna, SE17176 Stockholm, Sweden., Marcotte H; Department of Medical Biochemistry and Biophysics, Umeå University, SE90187 Umeå, Sweden.; Division of Clinical Immunology and Transfusion Medicine, Karolinska Institutet at Karolinska University Hospital, SE14186 Huddinge, Sweden.; Department of Biosciences and Nutrition, Karolinska Institutet, SE14183, Huddinge, Sweden., Sjöström R; Department of Medical Biochemistry and Biophysics, Umeå University, SE90187 Umeå, Sweden., Shevtsova A; Department of Medical Biochemistry and Biophysics, Umeå University, SE90187 Umeå, Sweden., Bylund G; Department of Medical Biochemistry and Biophysics, Umeå University, SE90187 Umeå, Sweden., Rakhimova L; Department of Medical Biochemistry and Biophysics, Umeå University, SE90187 Umeå, Sweden.; Present address: Department of Odontology, Umeå University, SE90187 Umeå, Sweden., Lundquist A; Department of Statistics, USBE, Umeå University, SE90187 Umeå, Sweden.; Umeå Center for Functional Brain Imaging, Umeå University, SE90187 Umeå, Sweden., Berhilevych O; Department of Public Health, Medical Institute, Sumy State University, 40007 Sumy, Ukraine., Kasianchuk V; Department of Public Health, Medical Institute, Sumy State University, 40007 Sumy, Ukraine., Loboda A; Department of Pediatrics, Medical Institute, Sumy State University, 40018 Sumy, Ukraine., Ivanytsia V; Department of Microbiology, Virology and Biotechnology, Odesa Mechnikov National University, 65082 Odesa, Ukraine., Hultenby K; Departments of Laboratory Medicine, Division of Biomolecular and Cellular Medicine, Karolinska Institutet at Karolinska University Hospital, SE14186 Huddinge, Sweden., Persson MAA; Department of Clinical Neuroscience, Karolinska Institutet at Center for Molecular Medicine, Karolinska University Hospital, Solna, SE17176 Stockholm, Sweden., Gomes J; i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal.; IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto, 4200-135 Porto, Portugal., Matos R; i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal.; IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto, 4200-135 Porto, Portugal., Gartner F; i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal.; IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto, 4200-135 Porto, Portugal.; Instituto de Ciências Biomédicas Abel Salazar, University of Porto, 4050-313 Porto, Portugal., Reis CA; i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal.; IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto, 4200-135 Porto, Portugal.; Instituto de Ciências Biomédicas Abel Salazar, University of Porto, 4050-313 Porto, Portugal.; Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal., Whitmire JM; Department of Microbiology and Immunology, USUHS, Bethesda, MD 20814, USA., Merrell DS; Department of Microbiology and Immunology, USUHS, Bethesda, MD 20814, USA., Pan-Hammarström Q; Department of Biosciences and Nutrition, Karolinska Institutet, SE14183, Huddinge, Sweden., Landström M; Present address: Department of Medical Biosciences, Umeå University, SE90185 Umeå, Sweden., Oscarson S; Centre for Synthesis and Chemical Biology, School of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland., D'Elios MM; Department of Experimental and Clinical Medicine, Largo Brambilla 3, 50134 Firenze, Italy., Agreus L; Division of Family Medicine and Primary Care, Karolinska Institutet, SE14183 Huddinge, Sweden., Ronkainen J; University of Oulu, Center for Life Course Health Research and Primary Health Care Center, Tornio Finland., Aro P; University of Oulu, Center for Life Course Health Research and Primary Health Care Center, Tornio Finland., Engstrand L; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, SE17177 Stockholm, Sweden.; Present address: Science for Life Laboratory, SE17165, Solna, Sweden., Graham DY; Department of Medicine, Molecular Virology and Microbiology, Baylor College of Medicine, Michael E. DeBakey VAMC, 2002 Holcombe Blvd. Houston, TX, 77030 USA., Kachkovska V; Department of Internal Medicine, Medical Institute, Sumy State University, 40007 Sumy, Ukraine., Mukhopadhyay A; Division of Bacteriology, ICMR-National Institute of Cholera and Enteric Diseases P 33, CIT Road, Scheme XM, Kolkata 700010, India., Chaudhuri S; Department of Gastroenterology, AMRI Hospital, Salt Lake City. Kolkata, West Bengal 700098, India., Karmakar BC; Division of Bacteriology, ICMR-National Institute of Cholera and Enteric Diseases P 33, CIT Road, Scheme XM, Kolkata 700010, India., Paul S; Division of Bacteriology, ICMR-National Institute of Cholera and Enteric Diseases P 33, CIT Road, Scheme XM, Kolkata 700010, India., Kravets O; Department of Surgery, Traumatology, Orthopedics and Physiology, Medical Institute, Sumy State University, 40007 Sumy, Ukraine., Camorlinga M; Unidad de Investigacion en Enfermedades Infecciosas, UMAE Pediatria, CMN SXXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico., Torres J; Unidad de Investigacion en Enfermedades Infecciosas, UMAE Pediatria, CMN SXXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico., Berg DE; Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA., Moskalenko R; SUMEYA, The Ukrainian-Swedish Research Center, Sumy State University, 40022 Sumy, Ukraine.; Department of Pathology, Medical Institute, Sumy State University, 40007 Sumy, Ukraine., Haas R; German Center for Infection Research (DZIF), Munich Site, 80336 Munich, Germany.; Chair of Medical Microbiology and Hospital Epidemiology, Max von Pettenkofer-Institute, Faculty of Medicine, LMU Munich, Germany., Remaut H; Structural and Molecular Microbiology, VIB Department of Structural Biology, VIB, 1050 Brussels, Belgium.; Structural Biology Brussels, Vrije Universiteit Brussel, 1050 Brussels, Belgium., Hammarström L; Department of Biosciences and Nutrition, Karolinska Institutet, SE14183, Huddinge, Sweden., Borén T; Department of Medical Biochemistry and Biophysics, Umeå University, SE90187 Umeå, Sweden.; SUMEYA, The Ukrainian-Swedish Research Center, Sumy State University, 40022 Sumy, Ukraine.; Lead contact.
Jazyk:	angličtina
Zdroj:	BioRxiv : the preprint server for biology [bioRxiv] 2023 May 24. Date of Electronic Publication: 2023 May 24.
DOI:	10.1101/2023.05.24.542096
Abstrakt:	The majority of the world population carry the gastric pathogen Helicobacter pylori . Fortunately, most individuals experience only low-grade or no symptoms, but in many cases the chronic inflammatory infection develops into severe gastric disease, including duodenal ulcer disease and gastric cancer. Here we report on a protective mechanism where H. pylori attachment and accompanying chronic mucosal inflammation can be reduced by antibodies that are present in a vast majority of H. pylori carriers. These antibodies block binding of the H. pylori attachment protein BabA by mimicking BabA's binding to the ABO blood group glycans in the gastric mucosa. However, many individuals demonstrate low titers of BabA blocking antibodies, which is associated with an increased risk for duodenal ulceration, suggesting a role for these antibodies in preventing gastric disease. Competing Interests: DECLARATION OF INTERESTS The authors declare the following competing interests: T. Borén and L. Hammarström are founders of Helicure AB and, own the IP-rights to the anti-BabA ABbA-IgG1 (US patent US8025880B2) and own the IP-rights to the gastric cancer vaccine and diagnostics described in the two manuscripts by Bugaytsova et al., 2023 (Patent Application SE 2350423-6).
Databáze:	MEDLINE
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