Activation of cytosolic RNA sensors by endogenous ligands: roles in disease pathogenesis.

Autor:	Straub S; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, Australia.; Department of Molecular and Translational Sciences, School of Clinical Sciences, Monash University, Clayton, VIC, Australia., Sampaio NG; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, Australia.; Department of Molecular and Translational Sciences, School of Clinical Sciences, Monash University, Clayton, VIC, Australia.
Jazyk:	angličtina
Zdroj:	Frontiers in immunology [Front Immunol] 2023 May 24; Vol. 14, pp. 1092790. Date of Electronic Publication: 2023 May 24 (Print Publication: 2023).
DOI:	10.3389/fimmu.2023.1092790
Abstrakt:	Early detection of infection is a central and critical component of our innate immune system. Mammalian cells have developed specialized receptors that detect RNA with unusual structures or of foreign origin - a hallmark of many virus infections. Activation of these receptors induces inflammatory responses and an antiviral state. However, it is increasingly appreciated that these RNA sensors can also be activated in the absence of infection, and that this 'self-activation' can be pathogenic and promote disease. Here, we review recent discoveries in sterile activation of the cytosolic innate immune receptors that bind RNA. We focus on new aspects of endogenous ligand recognition uncovered in these studies, and their roles in disease pathogenesis. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Straub and Sampaio.)
Databáze:	MEDLINE
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