Immunohistochemical Analysis of Lung Adenocarcinoma in Russian Mayak Nuclear Workers.

Autor: Sychugov GV; South Ural State Medical University, Ministry of Health, Chelyabinsk, Russia., Azizova TV; Southern Urals Biophysics Institute, Russian Federal Medical Biological Agency, Ozyorsk, Russia., Zhuntova GV; Southern Urals Biophysics Institute, Russian Federal Medical Biological Agency, Ozyorsk, Russia., Grigoryeva ES; Southern Urals Biophysics Institute, Russian Federal Medical Biological Agency, Ozyorsk, Russia., Loffredo CA; Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia, USA., Hamada N; Biology and Environmental Chemistry Division, Sustainable System Research Laboratory, Central Research Institute of Electric Power Industry (CRIEPI), Chiba, Japan., Kazachkov EL; South Ural State Medical University, Ministry of Health, Chelyabinsk, Russia.
Jazyk: angličtina
Zdroj: Cancer investigation [Cancer Invest] 2023 Sep; Vol. 41 (7), pp. 686-698. Date of Electronic Publication: 2023 Jun 09.
DOI: 10.1080/07357907.2023.2218489
Abstrakt: Specimens of lung adenocarcinoma (AdCa) from Russian nuclear workers ( n  = 54) exposed to alpha particles and gamma rays and from individuals non-exposed to radiation ( n  = 21) were examined using immunohistochemistry. Estimated significant associations with alpha dose were negative for Ki-67 and collagen IV in AdCa. Associations with gamma-ray dose were negative for tissue inhibitor of matrix metalloproteinase 2 and caspase 3 and positive for matrix metalloproteinase 2 and leukemia inhibiting factor in AdCa. The findings provide some evidence supporting alterations in apoptosis, cell proliferation and extracellular matrix in lung tissues affected by chronic radiation exposure that can contribute to radiogenic cancerogenesis.
Databáze: MEDLINE
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