Sex differences in the influence of type 2 diabetes (T2D)-related genes, parental history of T2D, and obesity on T2D development: a case-control study.

Autor: Berumen J; Unidad de Investigación en Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, Cuauhtémoc, 06720, Ciudad de Mexico, México. jaimeberumen47@gmail.com., Orozco L; Instituto Nacional de Medicina Genómica, Ciudad de Mexico, México., Gallardo-Rincón H; Universidad of Guadalajara, Health Sciences University Center, Guadalajara, Jalisco, México. hgallardo@fundacioncarlosslim.org.; Fundación Carlos Slim, Lago Zurich 245, Presa Falcon Building (Floor 20), Col. Ampliacion Granada, Miguel Hidalgo, 11529, Mexico City, México. hgallardo@fundacioncarlosslim.org., Rivas F; Unidad de Investigación en Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, Cuauhtémoc, 06720, Ciudad de Mexico, México., Barrera E; Unidad de Investigación en Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, Cuauhtémoc, 06720, Ciudad de Mexico, México., Benuto RE; Laboratorio Huella Génica, Ciudad de Mexico, México., García-Ortiz H; Instituto Nacional de Medicina Genómica, Ciudad de Mexico, México., Marin-Medina M; Laboratorio Huella Génica, Ciudad de Mexico, México., Juárez-Torres E; Laboratorio Huella Génica, Ciudad de Mexico, México., Alvarado-Silva A; Laboratorio Huella Génica, Ciudad de Mexico, México., Ramos-Martinez E; Unidad de Investigación en Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, Cuauhtémoc, 06720, Ciudad de Mexico, México., MartÍnez-Juárez LA; Fundación Carlos Slim, Lago Zurich 245, Presa Falcon Building (Floor 20), Col. Ampliacion Granada, Miguel Hidalgo, 11529, Mexico City, México., Lomelín-Gascón J; Fundación Carlos Slim, Lago Zurich 245, Presa Falcon Building (Floor 20), Col. Ampliacion Granada, Miguel Hidalgo, 11529, Mexico City, México., Montoya A; Fundación Carlos Slim, Lago Zurich 245, Presa Falcon Building (Floor 20), Col. Ampliacion Granada, Miguel Hidalgo, 11529, Mexico City, México., Ortega-Montiel J; Fundación Carlos Slim, Lago Zurich 245, Presa Falcon Building (Floor 20), Col. Ampliacion Granada, Miguel Hidalgo, 11529, Mexico City, México., Alvarez-Hernández DA; Fundación Carlos Slim, Lago Zurich 245, Presa Falcon Building (Floor 20), Col. Ampliacion Granada, Miguel Hidalgo, 11529, Mexico City, México., Larriva-Shad J; Instituto de Neurobiología, Universidad Nacional Autónoma de México, Juriquilla, Querétaro, México., Tapia-Conyer R; Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de Mexico, México.
Jazyk: angličtina
Zdroj: Biology of sex differences [Biol Sex Differ] 2023 Jun 08; Vol. 14 (1), pp. 39. Date of Electronic Publication: 2023 Jun 08.
DOI: 10.1186/s13293-023-00521-y
Abstrakt: Background: This study investigated the effect of sex and age at type 2 diabetes (T2D) diagnosis on the influence of T2D-related genes, parental history of T2D, and obesity on T2D development.
Methods: In this case-control study, 1012 T2D cases and 1008 healthy subjects were selected from the Diabetes in Mexico Study database. Participants were stratified by sex and age at T2D diagnosis (early, ≤ 45 years; late, ≥ 46 years). Sixty-nine T2D-associated single nucleotide polymorphisms were explored and the percentage contribution (R 2 ) of T2D-related genes, parental history of T2D, and obesity (body mass index [BMI] and waist-hip ratio [WHR]) on T2D development was calculated using univariate and multivariate logistic regression models.
Results: T2D-related genes influenced T2D development most in males who were diagnosed early (R 2  = 23.5%; females, R 2  = 13.5%; males and females diagnosed late, R 2  = 11.9% and R 2  = 7.3%, respectively). With an early diagnosis, insulin production-related genes were more influential in males (76.0% of R 2 ) while peripheral insulin resistance-associated genes were more influential in females (52.3% of R 2 ). With a late diagnosis, insulin production-related genes from chromosome region 11p15.5 notably influenced males while peripheral insulin resistance and genes associated with inflammation and other processes notably influenced females. Influence of parental history was higher among those diagnosed early (males, 19.9%; females, 17.5%) versus late (males, 6.4%; females, 5,3%). Unilateral maternal T2D history was more influential than paternal T2D history. BMI influenced T2D development for all, while WHR exclusively influenced males.
Conclusions: The influence of T2D-related genes, maternal T2D history, and fat distribution on T2D development was greater in males than females.
(© 2023. The Author(s).)
Databáze: MEDLINE
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