Targeting lymphoid-derived IL-17 signaling to delay skin aging.

Autor: Solá P; Institute for Research in Biomedicine, Barcelona Institute of Science and Technology, Barcelona, Spain., Mereu E; Josep Carreras Leukemia Research Institute, Badalona, Spain., Bonjoch J; Institute for Research in Biomedicine, Barcelona Institute of Science and Technology, Barcelona, Spain., Casado-Peláez M; Josep Carreras Leukemia Research Institute, Badalona, Spain., Prats N; Institute for Research in Biomedicine, Barcelona Institute of Science and Technology, Barcelona, Spain., Aguilera M; Institute for Research in Biomedicine, Barcelona Institute of Science and Technology, Barcelona, Spain., Reina O; Institute for Research in Biomedicine, Barcelona Institute of Science and Technology, Barcelona, Spain., Blanco E; Centre for Genomic Regulation, Barcelona Institute of Science and Technology, Barcelona, Spain., Esteller M; Josep Carreras Leukemia Research Institute, Badalona, Spain.; ICREA, Catalan Institution for Research and Advanced Studies, Barcelona, Spain., Di Croce L; Centre for Genomic Regulation, Barcelona Institute of Science and Technology, Barcelona, Spain.; ICREA, Catalan Institution for Research and Advanced Studies, Barcelona, Spain., Heyn H; Centre for Genomic Regulation, Barcelona Institute of Science and Technology, Barcelona, Spain. holger.heyn@cnag.crg.eu., Solanas G; Institute for Research in Biomedicine, Barcelona Institute of Science and Technology, Barcelona, Spain. guiomar.solanas@irbbarcelona.org., Benitah SA; Institute for Research in Biomedicine, Barcelona Institute of Science and Technology, Barcelona, Spain. salvador.aznar-benitah@irbbarcelona.org.; ICREA, Catalan Institution for Research and Advanced Studies, Barcelona, Spain. salvador.aznar-benitah@irbbarcelona.org.
Jazyk: angličtina
Zdroj: Nature aging [Nat Aging] 2023 Jun; Vol. 3 (6), pp. 688-704. Date of Electronic Publication: 2023 Jun 08.
DOI: 10.1038/s43587-023-00431-z
Abstrakt: Skin aging is characterized by structural and functional changes that contribute to age-associated frailty. This probably depends on synergy between alterations in the local niche and stem cell-intrinsic changes, underscored by proinflammatory microenvironments that drive pleotropic changes. The nature of these age-associated inflammatory cues, or how they affect tissue aging, is unknown. Based on single-cell RNA sequencing of the dermal compartment of mouse skin, we show a skew towards an IL-17-expressing phenotype of T helper cells, γδ T cells and innate lymphoid cells in aged skin. Importantly, in vivo blockade of IL-17 signaling during aging reduces the proinflammatory state of the skin, delaying the appearance of age-related traits. Mechanistically, aberrant IL-17 signals through NF-κB in epidermal cells to impair homeostatic functions while promoting an inflammatory state. Our results indicate that aged skin shows signs of chronic inflammation and that increased IL-17 signaling could be targeted to prevent age-associated skin ailments.
(© 2023. The Author(s).)
Databáze: MEDLINE
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