A systematic review and meta-analysis of randomized controlled trials to evaluate plant-based omega-3 polyunsaturated fatty acids in nonalcoholic fatty liver disease patient biomarkers and parameters.

Autor:	Moore E; Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom., Patanwala I; Manchester Royal Infirmary, Manchester, United Kingdom., Jafari A; Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran., Davies IG; Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom., Kirwan RP; Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom., Newson L; School of Psychology, Liverpool John Moores University, Liverpool, United Kingdom., Mazidi M; Medical Research Council Population Health Research Unit, Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.; Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom., Lane KE; Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom.
Jazyk:	angličtina
Zdroj:	Nutrition reviews [Nutr Rev] 2024 Jan 10; Vol. 82 (2), pp. 143-165.
DOI:	10.1093/nutrit/nuad054
Abstrakt:	Context: Nonalcoholic fatty liver disease (NAFLD) is prevalent in 25-30% of British and European populations, representing a potential global public health crisis. Marine omega-3 (n-3) polyunsaturated fatty acids offer well-evidenced benefits to NAFLD biomarkers; however, the effect of plant-based n-3 has not been evaluated with a systematic review and meta-analysis. Objective: The review aimed to systematically evaluate the effect of plant-based n-3 supplementation on NAFLD surrogate biomarkers and parameters. Data Sources: Medline (EBSCO), PubMed, CINAHL (EBSCO), Cochrane Central Register of Controlled Trials, the International Clinical Trials Registry Platform, and Google Scholar databases were searched to identify randomized controlled trials published between January 1970 and March 2022 evaluating the impact of plant-based n-3 interventions on diagnosed NAFLD. The review followed the PRISMA checklist and is PROSPERO registered (CRD42021251980). Data Extraction: A random-effects model and generic inverse variance methods synthesized quantitative data, followed by a leave-one-out method for sensitivity analysis. We identified 986 articles; after the application of selection criteria, six studies remained with 362 patients with NAFLD. Results: The meta-analysis showed that plant-based n-3 fatty acid supplementation significantly reduced alanine aminotransferase (ALT) (mean difference: 8.04 IU/L; 95% confidence interval: 14.70, 1.38; I2 = 48.61%) and plasma/serum triglycerides (44.51 mg/dL; 95% confidence interval: -76.93, -12.08; I2 = 69.93%), alongside body-composition markers in patients with NAFLD (P < 0.05). Conclusion: Plant-based n-3 fatty acid supplementation improves ALT enzyme biomarkers, triglycerides, body mass index, waist circumference, and weight loss when combined with lifestyle interventions to increase physical activity and a calorie-controlled diet. Further research is needed to identify the most effective plant-based n-3 sources in larger numbers of patients with NAFLD over longer study durations. Systematic Review Registration: PROSPERO registration no. CRD42021251980. (© The Author(s) 2023. Published by Oxford University Press on behalf of the International Life Sciences Institute.)
Databáze:	MEDLINE
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