Neutrophil-to-lymphocyte ratio and lymphocyte count reflect alterations in central neurodegeneration-associated proteins and clinical severity in Parkinson Disease patients.

Autor: Grillo P; Unit of Neurology, Department of Systems Medicine, University of Roma Tor Vergata, Rome, Italy; Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy., Sancesario GM; Clinical Neurochemistry Laboratory, IRCCS Fondazione Santa Lucia, Rome, Italy., Bovenzi R; Unit of Neurology, Department of Systems Medicine, University of Roma Tor Vergata, Rome, Italy., Zenuni H; Unit of Neurology, Department of Systems Medicine, University of Roma Tor Vergata, Rome, Italy., Bissacco J; Unit of Neurology, Department of Systems Medicine, University of Roma Tor Vergata, Rome, Italy., Mascioli D; Unit of Neurology, Department of Systems Medicine, University of Roma Tor Vergata, Rome, Italy., Simonetta C; Unit of Neurology, Department of Systems Medicine, University of Roma Tor Vergata, Rome, Italy., Forti P; Unit of Neurology, Department of Systems Medicine, University of Roma Tor Vergata, Rome, Italy., Degoli GR; Unit of Neurology, Department of Systems Medicine, University of Roma Tor Vergata, Rome, Italy., Pieri M; Department of Experimental Medicine, University of Roma Tor Vergata, Rome, Italy., Chiurchiù V; Institute of Translational Pharmacology, National Research Council, Rome, Italy; Laboratory of Resolution of Neuroinflammation, IRCCS Santa Lucia Foundation, Rome, Italy., Stefani A; Unit of Neurology, Department of Systems Medicine, University of Roma Tor Vergata, Rome, Italy., Mercuri NB; Unit of Neurology, Department of Systems Medicine, University of Roma Tor Vergata, Rome, Italy; Experimental Neurology Unit, IRCCS Fondazione Santa Lucia, Rome, Italy., Schirinzi T; Unit of Neurology, Department of Systems Medicine, University of Roma Tor Vergata, Rome, Italy. Electronic address: t.schirinzi@yahoo.com.
Jazyk: angličtina
Zdroj: Parkinsonism & related disorders [Parkinsonism Relat Disord] 2023 Jul; Vol. 112, pp. 105480. Date of Electronic Publication: 2023 Jun 04.
DOI: 10.1016/j.parkreldis.2023.105480
Abstrakt: Introduction: Peripheral inflammation has been recently associated to Parkinson disease (PD). However, how the peripheral inflammatory immune response could affect the clinical-pathological features of the disease is not fully understood. In this study, we assessed the peripheral immune profile of a well-characterized PD cohort, examining several correlations with CSF biomarkers of neurodegeneration and the main clinical parameters, aimed at better elucidating the complex dynamics of the brain-periphery interactions in PD.
Methods: The leukocyte populations counts (neutrophils, lymphocytes, monocytes, eosinophils, and basophils) and the neutrophil-to-lymphocyte ratio (NLR) were collected and compared in 61 PD patients and 60 sex/age matched controls (CTRLs). Immune parameters were correlated with CSF levels of total α-synuclein, amyloid-β-42, total and phosphorylated-tau and main motor and non-motor scores.
Results: PD patients had lower lymphocyte and higher NLR counts compared to CTRLs. In PD patients, the lymphocyte count directly correlated with CSF α-synuclein levels, whereas NLR displayed an inverse correlation with the CSF amyloid-β42 levels. The lymphocyte count also negatively correlated with HY stage, while NLR positively with the disease duration.
Conclusions: This study provided in vivo evidence that, in PD, changes in leukocytes in the periphery, assessed as relative lymphopenia and NLR increase, reflect in central neurodegeneration-associated proteins modifications, especially in α-synuclein and amyloid-β pathways, and greater clinical burden.
Competing Interests: Declaration of competing interest None.
(Copyright © 2023 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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