A large particle size is required by a nano/micron sized-fluticasone propionate inhalable suspension for asthma treatment.

Autor: Zhang M; School of Pharmacy, Xuzhou Medical University, Xuzhou 221004, China., Si SJ; School of Pharmacy, Xuzhou Medical University, Xuzhou 221004, China., Dai WJ; School of Pharmacy, Xuzhou Medical University, Xuzhou 221004, China., Yang J; The Affiliated Lianyungang Hospital of Xuzhou Medical University, 222002, China., Wang Y; School of Pharmacy, Xuzhou Medical University, Xuzhou 221004, China., Wei XR; School of Pharmacy, Xuzhou Medical University, Xuzhou 221004, China., Liu S; School of Pharmacy, Xuzhou Medical University, Xuzhou 221004, China., Xu CY; School of Pharmacy, Xuzhou Medical University, Xuzhou 221004, China., Zhang C; Shanghai Fangyu Health Pharmaceutical Technology Co., Ltd, Shanghai 200000, China., Jin F; School of Pharmacy, Xuzhou Medical University, Xuzhou 221004, China. Electronic address: jinfang@joincare.com., Jiang LQ; School of Pharmacy, Xuzhou Medical University, Xuzhou 221004, China. Electronic address: xiaojiang_235@163.com.
Jazyk: angličtina
Zdroj: Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2023 Aug; Vol. 228, pp. 113364. Date of Electronic Publication: 2023 May 24.
DOI: 10.1016/j.colsurfb.2023.113364
Abstrakt: The nano/micron sized-fluticasone propionate inhalable suspension (FPs) is used for asthma treatment, and this study aimed to elucidate the effects of particle size on the absorption of FPs by various pulmonary cells and the subsequent therapeutic efficacy for asthma. FPs of 727, 1136 and 1612 nm were prepared, and an increase in diameter diminished the endocytosis and macropinocytosis of FPs by alveolar epithelial cells (A549 and Calu-3 cells) but facilitated their uptake by M2-like macrophages; results about the transport across Calu-3 monolayer showed the mucus layer was the main rate-limiting step for the uptake of FPs by epithelial cells; the animal tests showed that although a decrease in diameter improved the pulmonary absorption of FPs, the particle size did not affect the lung distribution of FPs; a further detection revealed that larger FPs were taken more effectively by alveolar macrophages and lymphocytes and exerted a better therapeutic effect on asthma than the smaller ones. This study showed that the particle size of FPs had a significant impact on their absorption, elimination and cellular distribution in the lung after inhalation and further on their effectiveness in asthma treatment, and the particle size of the nano/micron sized-FPs should be designed and optimized for asthma treatment on the premise of meeting the requirements of inhalation preparations.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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