Analysis of Cancer Research Projects in Sub-Saharan Africa: A Quantitative Perspective on Unmet Needs and Opportunities.

Autor:	Davies L; International Cancer Research Partnership, Cardiff, United Kingdom., Milner DA Jr; American Society for Clinical Pathology, Chicago, IL., Shulman LN; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA., Kyokunda L; Sir Ketumile Masire Teaching Hospital, University of Botswana, Gaborone, Botswana., Bedada A; Sir Ketumile Masire Teaching Hospital, University of Botswana, Gaborone, Botswana., Vuylsteke P; Sir Ketumile Masire Teaching Hospital, University of Botswana, Gaborone, Botswana., Masalu N; Catholic University of Health and Allied Sciences, Bugando Medical Center, Mwanza, Tanzania., Jackson P; Cancer Australia, Strawberry Hills, NSW, Australia., Jennings N; Bristol Myers Squibb, Princeton, NJ., Odunlami A; Bristol Myers Squibb, Princeton, NJ., Mtshali P; Bristol Myers Squibb Foundation, Johannesburg, Gauteng, South Africa., Dugan U; Parker Institute for Cancer Immunotherapy, San Francisco, CA.
Jazyk:	angličtina
Zdroj:	JCO global oncology [JCO Glob Oncol] 2023 Jun; Vol. 9, pp. e2200203.
DOI:	10.1200/GO.22.00203
Abstrakt:	Purpose: To evaluate the scope and types of cancer research projects in sub-Saharan Africa (SSA) to identify research gaps and inform future efforts. Methods: This retrospective observational study summarized information on cancer research projects in SSA from the International Cancer Research Partnership (ICRP) between 2015 and 2020, alongside 2020 cancer incidence and mortality data from the Global Cancer Observatory. SSA cancer research projects were identified as led by investigators in SSA countries, or by investigators in non-SSA countries with collaborators in SSA, or in database keyword searches. Projects from the Coalition for Implementation Research in Global Oncology (CIRGO) were also summarized. Results: A total of 1,846 projects were identified from the ICRP database, funded by 34 organizations in seven countries (only one, Cancer Association of South Africa, based in SSA); only 156 (8%) were led by SSA-based investigators. Most projects focused on virally induced cancers (57%). Across all cancer types, projects were most frequently related to cervical cancer (24%), Kaposi sarcoma (15%), breast cancer (10%), or non-Hodgkin lymphoma (10%). Gaps were observed for several cancers with higher incidence/mortality burden in SSA; for example, prostate cancer accounted for only 4% of projects but 8% of cancer-related deaths and 10% of new cases. Approximately 26% were dedicated to etiology. Treatment-related research declined over the study period (14%-7% of all projects), while projects related to prevention (15%-20%) and diagnosis/prognosis (15%-29%) increased. Fifteen CIRGO projects were identified; seven were relevant across multiple cancer types, and 12 focused either wholly or partially on cancer control (representing 50% of the total research effort). Conclusion: This analysis shows notable discrepancies between cancer burden and research projects and identifies opportunities for future strategic investments in cancer care in SSA.
Databáze:	MEDLINE
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