Taurine deficiency as a driver of aging.

Autor: Singh P; Metabolic Research Laboratories, National Institute of Immunology, New Delhi, India., Gollapalli K; Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA., Mangiola S; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia.; School of Cancer Medicine, La Trobe University, Bundoora, VIC, Australia.; Olivia Newton-John Cancer Research Institute, Heidelberg, VIC, Australia., Schranner D; Exercise Biology Group, Technical University of Munich, Munich, Germany.; Institute of Computational Biology, Helmholtz Zentrum München, Neuherberg, Germany., Yusuf MA; Department of Bioengineering, Integral University, Lucknow, India., Chamoli M; Buck Institute for Research on Aging, Novato, CA, USA., Shi SL; Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA., Lopes Bastos B; Institute for Research on Cancer and Aging of Nice (IRCAN), Nice, France., Nair T; Molecular Aging Laboratory, National Institute of Immunology, New Delhi, India., Riermeier A; Exercise Biology Group, Technical University of Munich, Munich, Germany., Vayndorf EM; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA., Wu JZ; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA., Nilakhe A; Metabolic Research Laboratories, National Institute of Immunology, New Delhi, India., Nguyen CQ; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA., Muir M; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA., Kiflezghi MG; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA., Foulger A; Buck Institute for Research on Aging, Novato, CA, USA., Junker A; Department of Neurology, Columbia University, New York, NY, USA., Devine J; Department of Neurology, Columbia University, New York, NY, USA., Sharan K; Mouse Genetics Project, Wellcome Sanger Institute, Cambridge, UK., Chinta SJ; Buck Institute for Research on Aging, Novato, CA, USA., Rajput S; Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, India., Rane A; Buck Institute for Research on Aging, Novato, CA, USA., Baumert P; Exercise Biology Group, Technical University of Munich, Munich, Germany., Schönfelder M; Exercise Biology Group, Technical University of Munich, Munich, Germany., Iavarone F; Telethon Institute of Genetics and Medicine (TIGEM), Pozzuoli, Italy., di Lorenzo G; Telethon Institute of Genetics and Medicine (TIGEM), Pozzuoli, Italy., Kumari S; Metabolic Research Laboratories, National Institute of Immunology, New Delhi, India., Gupta A; Metabolic Research Laboratories, National Institute of Immunology, New Delhi, India., Sarkar R; Metabolic Research Laboratories, National Institute of Immunology, New Delhi, India., Khyriem C; Harry Perkins Institute of Medical Research, Perth, WA, Australia.; Curtin Medical School, Curtin University, Perth, WA, Australia., Chawla AS; Immunobiology Laboratory, National Institute of Immunology, New Delhi, India.; MRC-Protein Phosphorylation and Ubiquitination Unit, University of Dundee, Dundee, UK., Sharma A; Harry Perkins Institute of Medical Research, Perth, WA, Australia.; Curtin Medical School, Curtin University, Perth, WA, Australia., Sarper N; Pediatrics and Pediatric Hematology, Kocaeli University Hospital, Kocaeli, Turkey., Chattopadhyay N; Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, India., Biswal BK; Metabolic Research Laboratories, National Institute of Immunology, New Delhi, India., Settembre C; Telethon Institute of Genetics and Medicine (TIGEM), Pozzuoli, Italy.; Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy., Nagarajan P; Primate Research Facility, National Institute of Immunology, New Delhi, India.; Small Animal Research Facility, National Institute of Immunology, New Delhi, India., Targoff KL; Division of Cardiology, Department of Pediatrics, Columbia University, New York, NY, USA., Picard M; Department of Neurology, Columbia University, New York, NY, USA., Gupta S; Metabolic Research Laboratories, National Institute of Immunology, New Delhi, India., Velagapudi V; Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland., Papenfuss AT; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia., Kaya A; Department of Biology, Virginia Commonwealth University, Richmond, VA, USA., Ferreira MG; Institute for Research on Cancer and Aging of Nice (IRCAN), Nice, France., Kennedy BK; Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Centre for Healthy Longevity, National University Health System, Singapore, Singapore.; Departments of Biochemistry and Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Andersen JK; Buck Institute for Research on Aging, Novato, CA, USA., Lithgow GJ; Buck Institute for Research on Aging, Novato, CA, USA., Ali AM; Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Mukhopadhyay A; Molecular Aging Laboratory, National Institute of Immunology, New Delhi, India., Palotie A; Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland.; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., Kastenmüller G; Institute of Computational Biology, Helmholtz Zentrum München, Neuherberg, Germany., Kaeberlein M; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA., Wackerhage H; Exercise Biology Group, Technical University of Munich, Munich, Germany., Pal B; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia.; School of Cancer Medicine, La Trobe University, Bundoora, VIC, Australia.; Olivia Newton-John Cancer Research Institute, Heidelberg, VIC, Australia., Yadav VK; Metabolic Research Laboratories, National Institute of Immunology, New Delhi, India.; Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Mouse Genetics Project, Wellcome Sanger Institute, Cambridge, UK.; Department of Genetics and Development, Columbia University, New York, NY, USA.
Jazyk: angličtina
Zdroj: Science (New York, N.Y.) [Science] 2023 Jun 09; Vol. 380 (6649), pp. eabn9257. Date of Electronic Publication: 2023 Jun 09.
DOI: 10.1126/science.abn9257
Abstrakt: Aging is associated with changes in circulating levels of various molecules, some of which remain undefined. We find that concentrations of circulating taurine decline with aging in mice, monkeys, and humans. A reversal of this decline through taurine supplementation increased the health span (the period of healthy living) and life span in mice and health span in monkeys. Mechanistically, taurine reduced cellular senescence, protected against telomerase deficiency, suppressed mitochondrial dysfunction, decreased DNA damage, and attenuated inflammaging. In humans, lower taurine concentrations correlated with several age-related diseases and taurine concentrations increased after acute endurance exercise. Thus, taurine deficiency may be a driver of aging because its reversal increases health span in worms, rodents, and primates and life span in worms and rodents. Clinical trials in humans seem warranted to test whether taurine deficiency might drive aging in humans.
Databáze: MEDLINE
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