Fear memory recall involves hippocampal somatostatin interneurons.

Autor: Zichó K; Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Budapest, Hungary.; János Szentágothai Doctoral School of Neurosciences, Semmelweis University, Budapest, Hungary., Sos KE; Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Budapest, Hungary., Papp P; Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Budapest, Hungary., Barth AM; Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Budapest, Hungary., Misák E; Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Budapest, Hungary., Orosz Á; Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Budapest, Hungary., Mayer MI; Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Budapest, Hungary.; János Szentágothai Doctoral School of Neurosciences, Semmelweis University, Budapest, Hungary., Sebestény RZ; Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Budapest, Hungary., Nyiri G; Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Budapest, Hungary.
Jazyk: angličtina
Zdroj: PLoS biology [PLoS Biol] 2023 Jun 08; Vol. 21 (6), pp. e3002154. Date of Electronic Publication: 2023 Jun 08 (Print Publication: 2023).
DOI: 10.1371/journal.pbio.3002154
Abstrakt: Fear-related memory traces are encoded by sparse populations of hippocampal principal neurons that are recruited based on their inhibitory-excitatory balance during memory formation. Later, the reactivation of the same principal neurons can recall the memory. The details of this mechanism are still unclear. Here, we investigated whether disinhibition could play a major role in this process. Using optogenetic behavioral experiments, we found that when fear was associated with the inhibition of mouse hippocampal somatostatin positive interneurons, the re-inhibition of the same interneurons could recall fear memory. Pontine nucleus incertus neurons selectively inhibit hippocampal somatostatin cells. We also found that when fear was associated with the activity of these incertus neurons or fibers, the reactivation of the same incertus neurons or fibers could also recall fear memory. These incertus neurons showed correlated activity with hippocampal principal neurons during memory recall and were strongly innervated by memory-related neocortical centers, from which the inputs could also control hippocampal disinhibition in vivo. Nonselective inhibition of these mouse hippocampal somatostatin or incertus neurons impaired memory recall. Our data suggest a novel disinhibition-based memory mechanism in the hippocampus that is supported by local somatostatin interneurons and their pontine brainstem inputs.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2023 Zichó et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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