A Biomimicking and Multiarm Self-Indicating Nanoassembly for Site-Specific Photothermal-Potentiated Thrombolysis Assessed in Microfluidic and In Vivo Models.

Autor: Liu KT; Department of Chemical Engineering, National Taiwan University, Taipei, 10617, Taiwan., Quiñones ED; Department of Chemical Engineering, National Taiwan University, Taipei, 10617, Taiwan., Liu MH; Department of Chemical Engineering, National Taiwan University, Taipei, 10617, Taiwan., Lin CW; School of Biomedical Engineering, Taipei Medical University, Taipei, 11031, Taiwan., Chen YT; Graduate Institute of Nanomedicine and Medical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, 11031, Taiwan., Chiang CC; Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, 11031, Taiwan., Wu KC; Department of Chemical Engineering, National Taiwan University, Taipei, 10617, Taiwan.; Institute of Biomedical Engineering & Nanomedicine, National Health Research Institute, Keyan Road, Zhunan, Miaoli City, 350, Taiwan., Fan YJ; School of Biomedical Engineering, Taipei Medical University, Taipei, 11031, Taiwan.; Center for Precision Health and Quantitative Sciences, Taipei Medical University Hospital, Taipei, 11031, Taiwan., Chuang EY; School of Biomedical Engineering, Taipei Medical University, Taipei, 11031, Taiwan.; Graduate Institute of Nanomedicine and Medical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, 11031, Taiwan.; Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, 11031, Taiwan.; Cell Physiology and Molecular Image Research Center, Taipei Medical University-Wan Fang Hospital, Taipei, 11696, Taiwan., Yu J; Department of Chemical Engineering, National Taiwan University, Taipei, 10617, Taiwan.
Jazyk: angličtina
Zdroj: Advanced healthcare materials [Adv Healthc Mater] 2023 Sep; Vol. 12 (24), pp. e2300682. Date of Electronic Publication: 2023 Jun 14.
DOI: 10.1002/adhm.202300682
Abstrakt: Thrombolytic and antithrombotic therapies are limited by short circulation time and the risk of off-target hemorrhage. Integrating a thrombus-homing strategy with photothermal therapy are proposed to address these limitations. Using glycol chitosan, polypyrrole, iron oxide and heparin, biomimicking GCPIH nanoparticles are developed for targeted thrombus delivery and thrombolysis. The nanoassembly achieves precise delivery of polypyrrole, exhibiting biocompatibility, selective accumulation at multiple thrombus sites, and enhanced thrombolysis through photothermal activation. To simulate targeted thrombolysis, a microfluidic model predicting thrombolysis dynamics in realistic pathological scenarios is designed. Human blood assessments validate the precise homing of GCPIH nanoparticles to activated thrombus microenvironments. Efficient near-infrared phototherapeutic effects are demonstrated at thrombus lesions under physiological flow conditions ex vivo. The combined investigations provide compelling evidence supporting the potential of GCPIH nanoparticles for effective thrombus therapy. The microfluidic model also offers a platform for advanced thrombolytic nanomedicine development.
(© 2023 Wiley-VCH GmbH.)
Databáze: MEDLINE
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