A review for cell-based screening methods in drug discovery.
| Autor: | Wei F; Health Science Center, School of Pharmacy, Xi'an Jiaotong University, Xi'an 710061, China., Wang S; Health Science Center, School of Pharmacy, Xi'an Jiaotong University, Xi'an 710061, China., Gou X; Health Science Center, School of Pharmacy, Xi'an Jiaotong University, Xi'an 710061, China. |
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| Jazyk: | angličtina |
| Zdroj: | Biophysics reports [Biophys Rep] 2021 Dec 31; Vol. 7 (6), pp. 504-516. |
| DOI: | 10.52601/bpr.2021.210042 |
| Abstrakt: | With the biological relevance of the whole cells, low cost compared with animal experiments, a wide variety of cell-based screening platforms (cell-based assay, cell-based microfluidics, cell-based biosensor, cell-based chromatography) have been developed to address the challenges of drug discovery. In this review, we conclude the current advances in cell-based screening and summary the pros and cons of the platforms for different applications. Challenges and improvement strategies associated with cell-based methods are also discussed. Competing Interests: Fen Wei, Sicen Wang and Xilan Gou declare that they have no conflict of interest. (© The Author(s) 2021.) |
| Databáze: | MEDLINE |
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