Anti-nuclear matrix protein 2 antibody-positive dermatomyositis with gastrointestinal ulcers: A case report.

Autor: Uchio N; Department of Neurology, Mitsui Memorial Hospital, Tokyo, Japan., Komaki S; Department of Neurology, Mitsui Memorial Hospital, Tokyo, Japan., Sudo T; Department of Neurology, Mitsui Memorial Hospital, Tokyo, Japan., Matsumoto Y; Department of Neurology, Mitsui Memorial Hospital, Tokyo, Japan., Hao A; Department of Neurology, Mitsui Memorial Hospital, Tokyo, Japan., Kojima K; Department of Gastroenterology, Mitsui Memorial Hospital, Tokyo, Japan., Toda N; Department of Gastroenterology, Mitsui Memorial Hospital, Tokyo, Japan., Kitamura A; Department of Neurology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Maeda MH; Department of Neurology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Kubota A; Department of Neurology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Matsumoto H; Department of Neurology, Mitsui Memorial Hospital, Tokyo, Japan.
Jazyk: angličtina
Zdroj: International journal of rheumatic diseases [Int J Rheum Dis] 2023 Dec; Vol. 26 (12), pp. 2572-2575. Date of Electronic Publication: 2023 Jun 07.
DOI: 10.1111/1756-185X.14755
Abstrakt: Gastrointestinal manifestations are a very rare complication of dermatomyositis (DM) and are much less frequent in adult cases than in juvenile cases. Only a few previous papers have reported adult patients who had DM with anti-nuclear matrix protein 2 (anti-NXP2) antibodies and who developed gastrointestinal ulcers. Herein, we report a similar case of a 50-year-old man who had DM with anti-NXP2 antibodies followed by relapsing multiple gastrointestinal ulcers. Even after the administration of prednisolone, his muscle weakness and myalgia deteriorated and gastrointestinal ulcers relapsed. In contrast, intravenous immunoglobulin and azathioprine improved his muscle weakness and gastrointestinal ulcers. Based on the parallel disease activity of the muscular and gastrointestinal symptoms, we considered that his gastrointestinal ulcers were a complication of DM with anti-NXP2 antibodies. We also propose that early intensive immunosuppressive therapy would be required for the muscular and gastrointestinal symptoms in DM with anti-NXP2 antibodies.
(© 2023 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd.)
Databáze: MEDLINE
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