Four-years retention rate of golimumab administered after discontinuation of non-TNF inhibitors in patients with inflammatory rheumatic diseases.

Autor: Pombo-Suárez M; Department of Rheumatology, Hospital Universitario de Santiago de Compostela, Rúa da Choupana, S/N, 15706, Santiago de Compostela, A Coruña, Spain. mpombosuarez@gmail.com., Seoane-Mato D; Clinical Research Unit, Spanish Society of Rheumatology (SER), Madrid, Spain., Díaz-González F; Department of Rheumatology, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain.; Department of Internal Medicine, Dermatology and Psychiatry, Universidad de La Laguna, Santa Cruz de Tenerife, Spain.; Instituto de Tecnologías Biomédicas (ITB), Universidad de La Laguna, Santa Cruz de Tenerife, Spain., Sánchez-Alonso F; Clinical Research Unit, Spanish Society of Rheumatology (SER), Madrid, Spain., Sánchez-Jareño M; Medical Affairs, MSD Spain, Madrid, Spain., Cea-Calvo L; Medical Affairs, MSD Spain, Madrid, Spain., Castrejón I; Department of Rheumatology, Gregorio Marañón University Hospital, Madrid, Spain.
Jazyk: angličtina
Zdroj: Advances in rheumatology (London, England) [Adv Rheumatol] 2023 Jun 07; Vol. 63 (1), pp. 25. Date of Electronic Publication: 2023 Jun 07.
DOI: 10.1186/s42358-023-00296-1
Abstrakt: Background: In patients with rheumatic diseases, the use of biological (b) or targeted synthetic (ts) disease-modifying antirheumatic drugs (DMARDs) after discontinuation of tumor necrosis factor inhibitors (TNFi) is known to be effective. However, data on the use of TNFi after discontinuation of non-TNFi bDMARDs or tsDMARDs (non-TNFi) are scarce. This study assessed the 4-years golimumab retention in patients with rheumatic diseases when used after discontinuation of non-TNFi.
Methods: Adults with rheumatoid arthritis (RA; n = 72), psoriatic arthritis (PsA; n = 30) or axial spondyloarthritis (axSpA; n = 23) who initiated golimumab after discontinuation of non-TNFi from the Spanish registry of biological drugs (BIOBADASER) were analyzed retrospectively. The retention rate (drug survival or persistence) of golimumab up to 4 years was evaluated.
Results: The golimumab retention rate was 60.7% (51.4-68.8) at year 1, 45.9% (36.0-55.2) at year 2, 39.9% (29.8-49.7) at year 3 and 33.4% (23.0-44.2) at year 4. Retention rates did not differ significantly whether golimumab was used as second, third, or fourth/subsequent line of therapy (p log-rank = 0.462). Golimumab retention rates were higher in axSpA or PsA patients than in RA patients (p log-rank = 0.002). When golimumab was administered as third or fourth/subsequent line, the 4-years retention rate after discontinuation of non-TNFi was similar to that after discontinuation of TNFi.
Conclusion: In patients who discontinued non-TNFi, most of whom received golimumab as third/subsequent line of therapy, one-third of patients remained on golimumab at year 4. Retention rates were higher in patients with axSpA and PsA than in those with RA.
(© 2023. The Author(s).)
Databáze: MEDLINE
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