| Autor: |
Kumar P; Institute of Environmental Engineering, Ajou University, Suwon, South Korea., Park H; Department of Environmental Engineering, Ajou University, Suwon, South Korea., Yuk Y; Institute of Environmental Engineering, Ajou University, Suwon, South Korea., Kim H; Department of Life Science, Ajou University, Suwon, South Korea., Jang J; Institute of Environmental Engineering, Ajou University, Suwon, South Korea., Pagolu R; Institute of Environmental Engineering, Ajou University, Suwon, South Korea., Park S; Department of Environmental Engineering, Ajou University, Suwon, South Korea., Yeo C; Department of Environmental and Safety Engineering, Ajou University, Suwon, South Korea., Choi KY; Institute of Environmental Engineering, Ajou University, Suwon, South Korea.; Department of Environmental Engineering, Ajou University, Suwon, South Korea.; Department of Environmental and Safety Engineering, Ajou University, Suwon, South Korea.; Department of Energy Systems Research, Ajou University, Suwon, South Korea. |
| Abstrakt: |
1,4-Butanediol (1,4-BDO) is a valuable industrial chemical that is primarily produced via several energy-intensive petrochemical processes based on fossil-based raw materials, leading to issues related to: non-renewability, environmental contamination, and high production costs. 1,4-BDO is used in many chemical reactions to develop a variety of useful, valuable products, such as: polyurethane, Spandex intermediates, and polyvinyl pyrrolidone (PVP), a water-soluble polymer with numerous personal care and pharmaceutical uses. In recent years, to satisfy the growing need for 1,4-BDO, there has been a major shift in focus to sustainable bioproduction via microorganisms using: recombinant strains, metabolic engineering, synthetic biology, enzyme engineering, bioinformatics, and artificial intelligence-guided algorithms. This article discusses the current status of the development of: various chemical and biological production techniques for 1,4-BDO, advances in biological pathways for 1,4-BDO biosynthesis, prospects for future production strategies, and the difficulties associated with environmentally friendly and bio-based commercial production strategies. |
