The HPV-DNA Test in Pregnancy: A Review of the Literature.
| Autor: | Zagorianakou N; Cytology, University of Ioannina, Ioannina, GRC., Mitrogiannis I; Obstetrics & Gynecology, General Hospital of Arta, Arta, GRC., Konis K; Obstetrics & Gynecology, General Hospital of Arta, Arta, GRC., Makrydimas S; Medical School, Aristotle University of Thessaloniki, Thessaloniki, GRC., Mitrogiannis L; Anatomy, Histology, & Embryology, University of Ioannina, Ioannina, GRC., Makrydimas G; Obstetrics & Gynecology, University Hospital of Ioannina, Ioannina, GRC. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2023 May 06; Vol. 15 (5), pp. e38619. Date of Electronic Publication: 2023 May 06 (Print Publication: 2023). |
| DOI: | 10.7759/cureus.38619 |
| Abstrakt: | Human papillomavirus (HPV) is a virtually necessary cause of cervical cancer, and HPV genotypes are categorized either as high-risk or low-risk based on their potential to cause malignancy of the cervix. HPV-DNA detection is used widely for screening women at risk. However, its clinical significance is not proven sufficiently in pregnancy. The aim of this review was to summarize published data referring to the integration of the HPV-DNA test in cervical cancer screening during pregnancy. PubMed and Scopus were searched for articles investigating the HPV-DNA test during pregnancy as a primary association; greater interest was placed on studies published after 2000. Retrieved articles reported similarities or discrepancies in the HPV-DNA test in pregnant women compared to those who are not pregnant, its accuracy, and its integration in cervical cancer screening. The HPV-DNA test may constitute a helpful tool utilized for monitoring, risk stratification, and triage of cases that require colposcopy. If combined with the HPV-mRNA test, this might improve its specificity. However, when compared to HPV-DNA detection rates in non-pregnant women, the results were ambiguous, without giving the opportunity to draw safe conclusions. Both those findings and the high cost hold it back from wide use. Hence, the Papanicolaou smear (Pap smear) is still the first-line diagnostic tool and colposcopy-guided cervical biopsy is the "gold standard" method for the management of cervical intraepithelial neoplasia (CIN) treatment during pregnancy. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2023, Zagorianakou et al.) |
| Databáze: | MEDLINE |
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