Fusobacterium nucleatum dissemination by neutrophils.

Autor: Ellett F; Department of Surgery, Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Boston, MA, USA.; Shriners Hospital for Children, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Kacamak NI; The Forsyth Institute, Cambridge, MA, USA.; Harvard School of Dental Medicine, Boston, MA, USA., Alvarez CR; The Forsyth Institute, Cambridge, MA, USA.; Harvard School of Dental Medicine, Boston, MA, USA., Oliveira EHS; The Forsyth Institute, Cambridge, MA, USA.; Harvard School of Dental Medicine, Boston, MA, USA., Hasturk H; The Forsyth Institute, Cambridge, MA, USA.; Harvard School of Dental Medicine, Boston, MA, USA., Paster BJ; The Forsyth Institute, Cambridge, MA, USA.; Harvard School of Dental Medicine, Boston, MA, USA., Kantarci A; The Forsyth Institute, Cambridge, MA, USA.; Harvard School of Dental Medicine, Boston, MA, USA., Irimia D; Department of Surgery, Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Boston, MA, USA.; Shriners Hospital for Children, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.
Jazyk: angličtina
Zdroj: Journal of oral microbiology [J Oral Microbiol] 2023 Jun 04; Vol. 15 (1), pp. 2217067. Date of Electronic Publication: 2023 Jun 04 (Print Publication: 2023).
DOI: 10.1080/20002297.2023.2217067
Abstrakt: Recent studies uncovered that Fusobacterium nucleatum (Fn) , a common, opportunistic bacterium in the oral cavity, is associated with a growing number of systemic diseases, ranging from colon cancer to Alzheimer's disease. However, the pathological mechanisms responsible for this association are still poorly understood. Here, we leverage recent technological advances to study the interactions between Fn and neutrophils. We show that Fn survives within human neutrophils after phagocytosis. Using in vitro microfluidic devices, we determine that human neutrophils can protect and transport Fn over large distances. Moreover, we validate these observations in vivo by showing that neutrophils disseminate Fn using a zebrafish model. Our data support the emerging hypothesis that bacterial dissemination by neutrophils is a mechanistic link between oral and systemic diseases. Furthermore, our results may ultimately lead to therapeutic approaches that target specific host-bacteria interactions, including the dissemination process.
Competing Interests: No potential conflict of interest was reported by the author(s).
(© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.)
Databáze: MEDLINE
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