Incidence and characteristics of chronic postsurgical pain at 6 months after total mastectomy under pectoserratus and interpectoral plane block combined with general anesthesia: a prospective cohort study.

Autor:	Garcia V; Department of Anesthesiology, Intensive Care, Centre Oscar Lambret, Lille, Hauts-de-France, France v-garcia@o-lambret.fr., Wallet J; Department of Clinical Research and Innovation, Centre Oscar Lambret, Lille, Hauts-de-France, France., Leroux-Bromberg N; Department of Anesthesiology, Intensive Care, Centre Oscar Lambret, Lille, Hauts-de-France, France., Delbrouck D; Department of Anesthesiology, Intensive Care, Centre Oscar Lambret, Lille, Hauts-de-France, France., Hannebicque K; Department of Breast Surgery, Centre Oscar Lambret, Lille, Hauts-de-France, France., Ben Oune F; Department of Clinical Research and Innovation, Centre Oscar Lambret, Lille, Hauts-de-France, France., Léguillette C; Department of Clinical Research and Innovation, Centre Oscar Lambret, Lille, Hauts-de-France, France., Le Deley MC; Department of Clinical Research and Innovation, Centre Oscar Lambret, Lille, Hauts-de-France, France., Ahmeidi A; Department of Anesthesiology, Intensive Care, Centre Oscar Lambret, Lille, Hauts-de-France, France.
Jazyk:	angličtina
Zdroj:	Regional anesthesia and pain medicine [Reg Anesth Pain Med] 2024 Jan 11; Vol. 49 (1), pp. 36-40. Date of Electronic Publication: 2024 Jan 11.
DOI:	10.1136/rapm-2022-104185
Abstrakt:	Introduction: Chronic postsurgical pain (CPSP) occurs in 20%-30% of patients who undergo total mastectomy (TM) performed under general anesthesia alone and significantly affects the quality of life. Pectoserratus and interpectoral plane block have been reportedly combined with general anesthesia to control immediate postoperative pain after TM. Our prospective cohort study aimed to evaluate the incidence of CPSP after TM when pectoserratus and interpectoral plane block were combined with general anesthesia. Methods: We recruited adult women scheduled to undergo TM for breast cancer. Patients planned for TM with flap surgery, those who underwent breast surgery in the past 5 years, or those presenting with residual chronic pain after prior breast surgery were excluded. After general anesthesia induction, an anesthesiologist performed pectoserratus and interpectoral plane block with a ropivacaine (3.75 mg/mL) and clonidine (3.75 µg/mL) in 40 mL of 0.9% sodium chloride. The primary endpoint was the occurrence of CPSP-defined as pain with a Numeric Rating Scale Score of ≥3, either at the breast surgical site and/or at axilla, without other identifiable causes-evaluated during a pain medicine consultation at 6 months post TM. Results: Overall, 43/164 study participants had CPSP (26.2%; 95% CI: 19.7 to 33.6); of these, 23 had neuropathic type of pain (53.5%), 19 had nociceptive (44.2%), and 1 had mixed (2.3%) type of pain. Conclusion: Although postoperative analgesia has significantly improved in the last decade, there is still need for improvement to reduce CPSP after oncologic breast surgery. Trial Registration Number: NCT03023007. Competing Interests: Competing interests: None declared. (© American Society of Regional Anesthesia & Pain Medicine 2024. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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