Fatigue in Patients with Newly Diagnosed Inflammatory Bowel Disease: Results from a Prospective Inception Cohort, the IBSEN III Study.

Autor: Holten KIA; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.; Department of Gastroenterology, Østfold Hospital Trust, Sarpsborg, Norway., Bernklev T; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.; Research and Development Department, Vestfold Hospital Trust, Tønsberg, Norway., Opheim R; Department of Gastroenterology, Oslo University Hospital, Oslo, Norway.; Institute of Health and Society, Faculty of Medicine, University of Oslo, Oslo, Norway., Johansen I; Institute of Health and Society, Faculty of Medicine, University of Oslo, Oslo, Norway.; Department of Health Sciences, Østfold University College, Halden, Norway., Olsen BC; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.; Department of Gastroenterology, Telemark Hospital Trust, Skien, Norway., Lund C; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.; Department of Gastroenterology, Oslo University Hospital, Oslo, Norway., Strande V; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.; Unger-Vetlesen Institute, Lovisenberg Diaconal Hospital, Oslo, Norway.; Department of Gastroenterology, Lovisenberg Diaconal Hospital, Oslo, Norway., Medhus AW; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.; Department of Gastroenterology, Oslo University Hospital, Oslo, Norway., Perminow G; Pediatric Department, Oslo University Hospital, Oslo, Norway., Bengtson MB; Department of Medicine, Vestfold Hospital Trust, Tønsberg, Norway., Cetinkaya RB; Department of Medicine, Diakonhjemmet Hospital, Oslo, Norway., Vatn S; Department of Gastroenterology, Akershus University Hospital, Lørenskog, Norway., Frigstad SO; Department of Medicine, Vestre Viken Hospital Trust, Bærum, Norway., Aabrekk TB; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.; Department of Medicine, Vestfold Hospital Trust, Tønsberg, Norway., Detlie TE; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.; Department of Gastroenterology, Akershus University Hospital, Lørenskog, Norway., Hovde Ø; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.; Department of Medicine, Innlandet Hospital Trust, Gjøvik, Norway., Kristensen VA; Department of Gastroenterology, Oslo University Hospital, Oslo, Norway., Småstuen MC; Faculty of Health Sciences, Oslo Metropolitan University, Oslo, Norway., Henriksen M; Department of Gastroenterology, Østfold Hospital Trust, Sarpsborg, Norway., Huppertz-Hauss G; Department of Gastroenterology, Telemark Hospital Trust, Skien, Norway., Høivik ML; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.; Department of Gastroenterology, Oslo University Hospital, Oslo, Norway., Jelsness-Jørgensen LP; Department of Gastroenterology, Østfold Hospital Trust, Sarpsborg, Norway.; Department of Health Sciences, Østfold University College, Halden, Norway.
Jazyk: angličtina
Zdroj: Journal of Crohn's & colitis [J Crohns Colitis] 2023 Nov 24; Vol. 17 (11), pp. 1781-1790.
DOI: 10.1093/ecco-jcc/jjad094
Abstrakt: Background and Aims: Although fatigue is common in inflammatory bowel disease [IBD], its pathogenesis remains unclear. This study aimed to determine the prevalence of fatigue and its associated factors in a cohort of patients newly diagnosed with IBD.
Methods: Patients ≥18 years old were recruited from the Inflammatory Bowel Disease South-Eastern Norway [IBSEN III] study, a population-based, observational inception cohort. Fatigue was assessed using the Fatigue Questionnaire and compared with data from a Norwegian general population. Univariate and multivariate linear and logistic regression analyses were performed to evaluate the associations of total fatigue [TF; continuous score] and substantial fatigue [SF; dichotomized score ≥4] with sociodemographic, clinical, endoscopic, laboratory, and other relevant patient data.
Results: In total, 983/1509 [65.1%] patients with complete fatigue data were included (ulcerative colitis [UC], 68.2%; Crohn's disease [CD], 31.8%). The prevalence of SF was higher in CD [69.6%] compared with UC [60.2%] [p < 0.01], and in both diagnoses when compared to the general population [p < 0.001]. In multivariate analyses, depressive symptoms, pain intensity, and sleep disturbances were associated with increased TF for both diagnoses. In addition, increased clinical disease activity and Mayo endoscopic score were significantly associated with TF in UC, whereas all disease-related variables were insignificant in CD. Similar findings were observed for SF, except regarding the Mayo endoscopic score.
Conclusions: SF affects approximately two-thirds of patients newly diagnosed with IBD. Fatigue was associated with depressive symptoms, sleep disturbances, and increased pain intensity in both diagnoses, while clinical and endoscopic activity were associated factors only in UC.
(© The Author(s) 2023. Published by Oxford University Press on behalf of European Crohn’s and Colitis Organisation.)
Databáze: MEDLINE
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