Neuropathologic correlates of cerebral microbleeds in community-based older adults.

Autor: Nikseresht G; Department of Computer Science, Illinois Institute of Technology, Chicago, IL, USA; Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, USA., Evia AM; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA., Nag S; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA., Leurgans SE; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA., Capuano AW; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA., Agam G; Department of Computer Science, Illinois Institute of Technology, Chicago, IL, USA., Barnes LL; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA., Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA., Schneider JA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA., Arfanakis K; Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, USA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA; Department of Diagnostic Radiology, Rush University Medical Center, Chicago, IL, USA. Electronic address: konstantinos_arfanakis@rush.edu.
Jazyk: angličtina
Zdroj: Neurobiology of aging [Neurobiol Aging] 2023 Sep; Vol. 129, pp. 89-98. Date of Electronic Publication: 2023 May 08.
DOI: 10.1016/j.neurobiolaging.2023.05.005
Abstrakt: Cerebral microbleeds (CMBs) appearing as hypointense foci on T 2 *-weighted magnetic resonance images are small hemorrhages that have been linked to cognitive decline and increased mortality. However, the neuropathologic correlates of CMBs in community-based older adults are poorly understood. The present study investigated the association of age-related neuropathologies with CMBs in community-based older adults. Cerebral hemispheres from 289 participants of the Rush Memory and Aging Project, Religious Orders Study, Minority Aging Research Study, and Rush Alzheimer's Disease Clinical Core underwent ex vivo MRI and detailed neuropathologic examination. Following Bonferroni correction, CMBs in the cerebrum overall and in the frontal lobe were associated with cerebral amyloid angiopathy, CMBs in the frontal lobe were also associated with arteriolosclerosis, and CMBs in the basal ganglia showed a borderline significant association with microinfarcts. These findings suggest that CMBs can aid in the prediction of small vessel disease in community-based older adults. Finally, CMBs were not associated with dementia, suggesting that CMBs in community-based older adults may not be linked to substantial cognitive impairment.
Competing Interests: Disclosure Statement The authors have no financial interests or relationships to disclose with regard to the subject matter of this manuscript.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: