Structure-function associations between contrast sensitivity and widefield swept-source optical coherence tomography angiography in diabetic macular edema.
| Autor: | Baldwin G; Harvard Retinal Imaging Lab, Boston, MA, USA.; Retina Service, Massachusetts Eye and Ear, 243 Charles St, Boston, MA, 02114, USA., Vingopoulos F; Harvard Retinal Imaging Lab, Boston, MA, USA.; Retina Service, Massachusetts Eye and Ear, 243 Charles St, Boston, MA, 02114, USA., Garg I; Harvard Retinal Imaging Lab, Boston, MA, USA.; Retina Service, Massachusetts Eye and Ear, 243 Charles St, Boston, MA, 02114, USA., Moon JY; Harvard Retinal Imaging Lab, Boston, MA, USA.; Retina Service, Massachusetts Eye and Ear, 243 Charles St, Boston, MA, 02114, USA., Zeng R; Harvard Retinal Imaging Lab, Boston, MA, USA.; Retina Service, Massachusetts Eye and Ear, 243 Charles St, Boston, MA, 02114, USA., Cui Y; Harvard Retinal Imaging Lab, Boston, MA, USA.; Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China., Katz R; Harvard Retinal Imaging Lab, Boston, MA, USA., Le R; Harvard Retinal Imaging Lab, Boston, MA, USA.; Wenzhou Medical University Affiliated Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China., Lu ES; Harvard Retinal Imaging Lab, Boston, MA, USA.; Retina Service, Massachusetts Eye and Ear, 243 Charles St, Boston, MA, 02114, USA., Sayah DN; Harvard Retinal Imaging Lab, Boston, MA, USA.; Retina Service, Massachusetts Eye and Ear, 243 Charles St, Boston, MA, 02114, USA., Hassan Z; Harvard Retinal Imaging Lab, Boston, MA, USA., Kim LA; Retina Service, Massachusetts Eye and Ear, 243 Charles St, Boston, MA, 02114, USA., Elze T; Schepens Eye Research Institute of Massachusetts Eye and Ear, Boston, MA, USA., Husain D; Retina Service, Massachusetts Eye and Ear, 243 Charles St, Boston, MA, 02114, USA., Miller JB; Harvard Retinal Imaging Lab, Boston, MA, USA. John_Miller@meei.harvard.edu.; Retina Service, Massachusetts Eye and Ear, 243 Charles St, Boston, MA, 02114, USA. John_Miller@meei.harvard.edu. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie [Graefes Arch Clin Exp Ophthalmol] 2023 Nov; Vol. 261 (11), pp. 3113-3124. Date of Electronic Publication: 2023 Jun 06. |
| DOI: | 10.1007/s00417-023-06086-1 |
| Abstrakt: | Purpose: To evaluate the relationship between contrast sensitivity (CS) and widefield swept-source optical coherence tomography angiography (WF SS-OCTA) vascular metrics in diabetic macular edema (DME) was the purpose. Methods: This prospectively enrolled cross-sectional observational study included 61 eyes of 48 patients that were tested with the quantitative CS function (qCSF) test on the same day as imaging with WF SS-OCTA (PLEX® Elite 9000, Carl Zeiss Meditec) 3 × 3, 6 × 6, and 12 × 12 mm scans. Outcomes included visual acuity (VA) and multiple qCSF metrics. Vascular metrics included vessel density (VD) and vessel skeletonized density (VSD) in the superficial (SCP) and deep capillary plexus (DCP) and whole retina (WR) and foveal avascular zone (FAZ) parameters. Mixed effects multivariable linear regression models controlling for age, lens status, and diabetic retinopathy stage were performed. Standardized beta coefficients were calculated by refitting the standardized data. Results: SS-OCTA metrics had a significant association with CS and VA. The effect size of OCTA metrics was larger on CS compared to VA. For example, the standardized beta coefficients for VSD and CS at 3 cpd (β Conclusion: Structure-function associations in patients with DME leveraging the qCSF device suggest microvascular changes on WF SS-OCTA are associated with larger changes in contrast sensitivity than VA. (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|
Full text from SpringerLink