Diabetic wound healing potential of silk sericin protein based hydrogels enriched with plant extracts.

Autor: Zahoor S; Department of Zoology, Government College University Lahore, Pakistan. Electronic address: saimazahoor707@gmail.com., Tahir HM; Department of Zoology, Government College University Lahore, Pakistan. Electronic address: dr.hafiztahir@gcu.edu.pk., Ali S; Department of Zoology, Government College University Lahore, Pakistan. Electronic address: shaukatali134@yahoo.com., Ali A; Department of Zoology, Government College University Lahore, Pakistan. Electronic address: aamir.ali@gcu.edu.pk., Muzamil A; Department of Zoology, Government College University Lahore, Pakistan. Electronic address: ayeshamuzamil94@gmail.com., Murtaza Z; Department of Zoology, Government College University Lahore, Pakistan. Electronic address: zainabmurtaza.gcu@gmail.com., Zahoor N; Department of Botany, Government College University Lahore, Pakistan. Electronic address: nimbrazahoor@gmail.com.
Jazyk: angličtina
Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2023 Jul 01; Vol. 242 (Pt 4), pp. 125184. Date of Electronic Publication: 2023 Jun 03.
DOI: 10.1016/j.ijbiomac.2023.125184
Abstrakt: The complications associated with diabetic wounds make their healing process prolonged. Hydrogels could be ideal wound dressings therefore present research was conducted to prepare silk sericin (an adhesive protein polymer) based hydrogels in combination with plant extracts and to evaluate its effectiveness against wound healing process in mice with alloxan induced diabetes. Excision wounds were formed via a biopsy puncture (6 mm). Experimental hydrogels were prepared and applied topically on the diabetic wounds. All the hydrogel treatment groups showed significantly higher (P < 0.001) percent wound contraction from day 3 to day 11 as compared to the negative diabetic control group. The serum level of anti-inflammatory cytokine (Interleukin-10) and tissue inhibitor metalloproteinase (TIMP) was significantly higher (P < 0.001), while the level of pro-inflammatory cytokines (tumor necrosis factor-α, Interleukin-6) and matrix metalloproteinases (MMP-2, MMP-9) was significantly lower (P < 0.001) in hydrogels treatment groups as compared to diabetic control group. Although all the hydrogels showed effective results, however the best results were shown by 4 % sericin+4 % banyan+4 % onion based hydrogel. It can be concluded that Sericin based hydrogel enriched with banyan and onion extracts can be used as an effective remedy for the treatment of diabetic wounds due to their high healing and regenerative properties.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023. Published by Elsevier B.V.)
Databáze: MEDLINE
Externí odkaz: