The Association of Latitude and Altitude with COVID-19 Symptoms: A VIRUS: COVID-19 Registry Analysis.

Autor:	Tekin A; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN., Qamar S; Post-baccalaureate Research Education Program, Mayo Clinic College of Medicine and Science, Rochester, MN., Bansal V; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, MN., Surani S; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN.; Medical Critical Care Services, Texas A&M University, Corpus Christi, TX., Singh R; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN., Sharma M; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN., LeMahieu AM; Division of Clinical Trials and Biostatistics, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN., Hanson AC; Division of Clinical Trials and Biostatistics, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN., Schulte PJ; Division of Clinical Trials and Biostatistics, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN., Bogojevic M; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, MN., Deo N; Mayo Clinic Alix School of Medicine, Rochester, MN., Sanghavi DK; Department of Critical Care Medicine, Mayo Clinic, Jacksonville, FL., Cartin-Ceba R; Division of Pulmonary, Department of Medicine and Department of Critical Care Medicine. Mayo Clinic, Scottsdale, AZ., Jain NK; Division of Critical Care Medicine, Mayo Clinic Health System, Mankato, MN., Christie AB; Department of Critical Care, Atrium Health Navicent, Macon, GA., Sili U; Department of Infectious Diseases and Clinical Microbiology, Marmara University School of Medicine, Istanbul, Turkey., Anderson HL; Department of Surgery, St. Joseph Mercy Ann Arbor, Ann Arbor, MI., Denson JL; Section of Pulmonary, Critical Care, and Environmental Medicine, Tulane University School of Medicine, New Orleans, LA., Khanna AK; Wake Forest University School of Medicine; Wake Forest Baptist Health Network, Winston-Salem, NC.; Outcomes Research Consortium, Cleveland, OH., Zabolotskikh IB; Department of Anesthesiology, Intensive Care Medicine and Transfusiology, Kuban State Medical University with affiliation Territorial Hospital #2, Krasnodar, Russia., La Nou AT; Division of Critical Care Medicine, Mayo Clinic Health System, Eau Claire, WI., Akhter M; Department of Emergency Medicine, University of Arizona College of Medicine-Phoenix, Valleywise Health, Phoenix, AZ., Mohan SK; Panimalar Medical College Hospital & Research Institute, Varadharajapuram, Poonamallee, Chennai - 600 123, Tamil Nadu, India., Dodd KW; Department of Emergency Medicine, Advocate Christ Medical Center, Oak Lawn, IL.; Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Hennepin County Medical Center, Minneapolis, MN., Retford L; Society of Critical Care Medicine, Mount Prospect, IL., Boman K; Society of Critical Care Medicine, Mount Prospect, IL., Kumar VK; Society of Critical Care Medicine, Mount Prospect, IL., Walkey AJ; Pulmonary Center, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Evans Center of Implementation and Improvement Sciences, Boston University School of Medicine, Boston, MA., Gajic O; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, MN., Domecq JP; Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, MN., Kashyap R; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN.
Jazyk:	angličtina
Zdroj:	The open respiratory medicine journal [Open Respir Med J] 2022 Aug 31; Vol. 16, pp. e187430642207130. Date of Electronic Publication: 2022 Aug 31 (Print Publication: 2022).
DOI:	10.2174/18743064-v16-e2207130
Abstrakt:	Background: Better delineation of COVID-19 presentations in different climatological conditions might assist with prompt diagnosis and isolation of patients. Objectives: To study the association of latitude and altitude with COVID-19 symptomatology. Methods: This observational cohort study included 12267 adult COVID-19 patients hospitalized between 03/2020 and 01/2021 at 181 hospitals in 24 countries within the SCCM Discovery VIRUS: COVID-19 Registry. The outcome was symptoms at admission, categorized as respiratory, gastrointestinal, neurological, mucocutaneous, cardiovascular, and constitutional. Other symptoms were grouped as atypical. Multivariable regression modeling was performed, adjusting for baseline characteristics. Models were fitted using generalized estimating equations to account for the clustering. Results: The median age was 62 years, with 57% males. The median age and percentage of patients with comorbidities increased with higher latitude. Conversely, patients with comorbidities decreased with elevated altitudes. The most common symptoms were respiratory (80%), followed by constitutional (75%). Presentation with respiratory symptoms was not associated with the location. After adjustment, at lower latitudes (<30º), patients presented less commonly with gastrointestinal symptoms ( p< .001, odds ratios for 15º, 25º, and 30º: 0.32, 0.81, and 0.98, respectively). Atypical symptoms were present in 21% of the patients and showed an association with altitude ( p= .026, odds ratios for 75, 125, 400, and 600 meters above sea level: 0.44, 0.60, 0.84, and 0.77, respectively). Conclusions: We observed geographic variability in symptoms of COVID-19 patients. Respiratory symptoms were most common but were not associated with the location. Gastrointestinal symptoms were less frequent in lower latitudes. Atypical symptoms were associated with higher altitude. Competing Interests: Dr. Salim Surani is the Co-Editor of the journal Open Respiratory Medicine Journal. (© 2022 Tekin et al.)
Databáze:	MEDLINE
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