Single-cell transcriptomic analysis uncovers intratumoral heterogeneity and drug-tolerant persister in ALK-rearranged lung adenocarcinoma.

Autor: Kwok HH; Department of Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, P. R. China., Li H; Nancy B. and Jake L. Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA., Yang J; Department of Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, P. R. China., Deng J; Department of Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, P. R. China., Lee NC; Department of Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, P. R. China., Au TW; Cardiothoracic Surgical Department, Queen Mary Hospital, Hong Kong SAR, P. R. China., Sit AK; Cardiothoracic Surgical Department, Queen Mary Hospital, Hong Kong SAR, P. R. China., Hsin MK; Cardiothoracic Surgical Department, Queen Mary Hospital, Hong Kong SAR, P. R. China., Ma SK; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, P. R. China., Cheung LW; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, P. R. China., Girard L; Nancy B. and Jake L. Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA., Fujimoto J; Department of Translational Molecular Pathology, Division of Pathology/Lab Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Wistuba II; Department of Translational Molecular Pathology, Division of Pathology/Lab Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Gao B; Nancy B. and Jake L. Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA., Minna JD; Nancy B. and Jake L. Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA., Lam DC; Department of Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, P. R. China.
Jazyk: angličtina
Zdroj: Cancer communications (London, England) [Cancer Commun (Lond)] 2023 Aug; Vol. 43 (8), pp. 951-955. Date of Electronic Publication: 2023 Jun 04.
DOI: 10.1002/cac2.12449
Databáze: MEDLINE