Serum Vitamins A and E at Mid-Pregnancy and Their Relationships with Both Maternal and Cord Blood Antioxidant Status and Perinatal Conditions: The NELA Cohort.

Autor:	Sánchez-Campillo M; Department of Physiology, Faculty of Biology, University of Murcia, Murcia, Spain.; Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain., Gázquez A; Department of Physiology, Faculty of Biology, University of Murcia, Murcia, Spain.; Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain., Serrano-Munuera A; Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain., Arnao MB; Department of Plant Biology, Faculty of Biology, University of Murcia, Murcia, Spain., Avilés-Plaza F; Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain.; Molecular Therapy and Biomarkers Research Group, Clinical Analysis Service, Virgen de la Arrixaca University Clinical Hospital, University of Murcia, Murcia, Spain., Garcia-Serna AM; Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain.; Department of Public Health Sciences, Faculty of Medicine, University of Murcia, Murcia, Spain., Noguera-Velasco JA; Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain.; Molecular Therapy and Biomarkers Research Group, Clinical Analysis Service, Virgen de la Arrixaca University Clinical Hospital, University of Murcia, Murcia, Spain., Martínez-López de Castro A; Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain.; Molecular Therapy and Biomarkers Research Group, Clinical Analysis Service, Virgen de la Arrixaca University Clinical Hospital, University of Murcia, Murcia, Spain., Martínez-Graciá C; Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain.; Department of Food Science and Technology, Faculty of Veterinary, University of Murcia, Murcia, Spain., Suárez-Martínez C; Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain.; Department of Food Science and Technology, Faculty of Veterinary, University of Murcia, Murcia, Spain., Santaella-Pascual M; Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain.; Department of Food Science and Technology, Faculty of Veterinary, University of Murcia, Murcia, Spain., Vioque J; Health and Biomedical Research Institute of Alicante (ISABIAL-UMH), Alicante, Spain., Montoya-Hernández C; Obstetrics and Gynecology Service, Virgen de la Arrixaca University Clinical Hospital, University of Murcia, Murcia, Spain., Ballesteros-Meseguer C; Obstetrics and Gynecology Service, Virgen de la Arrixaca University Clinical Hospital, University of Murcia, Murcia, Spain., Sánchez-Ferrer M; Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain.; Obstetrics and Gynecology Service, Virgen de la Arrixaca University Clinical Hospital, University of Murcia, Murcia, Spain., Perez-Fernandez V; Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain.; Department of Sociosanitary Sciences, Faculty of Medicine, University of Murcia, Murcia, Spain., Morales E; Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain.; Department of Public Health Sciences, Faculty of Medicine, University of Murcia, Murcia, Spain., García-Marcos L; Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain.; Pediatric Allergy and Pulmonology Units, Virgen de la Arrixaca University Children's Hospital, University of Murcia, Murcia, Spain.; ARADyAL Allergy Network, Madrid, Spain., Larqué E; Department of Physiology, Faculty of Biology, University of Murcia, Murcia, Spain.; Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain.
Jazyk:	angličtina
Zdroj:	Annals of nutrition & metabolism [Ann Nutr Metab] 2023; Vol. 79 (3), pp. 313-325. Date of Electronic Publication: 2023 Jun 02.
DOI:	10.1159/000531239
Abstrakt:	Introduction: Most of the pregnant women do not achieve the recommended dietary intake of vitamins A and E. These vitamins may counteract oxidative stress involved in some adverse perinatal outcomes. We aimed to assess the associations between maternal vitamin A and E at mid-pregnancy with both maternal and fetal outcomes and to identify possible early biomarkers during pregnancy to predict and prevent oxidative stress in the offspring. Methods: Data on dietary and serum levels of vitamins A and E were collected from 544 pregnant women from the Nutrition in Early Life and Asthma (NELA) study, a prospective mother-child cohort set up in Spain. Results: There were large discrepancies between low dietary vitamin E intake (78% of the mothers) and low serum vitamin E levels (3%) at 24 weeks of gestation. Maternal serum vitamins A and E at mid-pregnancy were associated with higher antioxidant status not only in the mother at this time point (lower hydroperoxides and higher total antioxidant activity [TAA]) but also with the newborn at birth (higher TAA). Gestational diabetes mellitus (GDM) was negatively associated with maternal serum vitamin A (OR: 0.95 CI: 0.91-0.99, p = 0.009) at mid-pregnancy. Nevertheless, we could not detect any association between GDM and oxidative stress parameters. Conclusions: In conclusion, maternal vitamin A and E serum levels may be used as an early potential biomarker of antioxidant status of the neonate at birth. Control of these vitamins during pregnancy could help avoid morbid conditions in the newborn caused by oxidative stress in GDM pregnancies. (© 2023 S. Karger AG, Basel.)
Databáze:	MEDLINE
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