Docosahexaenoic acid and etanercept could reduce functional and metabolic alterations during collagen-induced arthritis in rats without any synergistic effect.

Autor: Léger T; Unité de Nutrition Humaine, UMR 1019, Université Clermont Auvergne, INRAE, CRNH Auvergne, F-63000 Clermont-Ferrand, France., Brun A; Unité de Nutrition Humaine, UMR 1019, Université Clermont Auvergne, INRAE, CRNH Auvergne, F-63000 Clermont-Ferrand, France., Lanchais K; Unité de Nutrition Humaine, UMR 1019, Université Clermont Auvergne, INRAE, CRNH Auvergne, F-63000 Clermont-Ferrand, France., Rigaudière JP; Unité de Nutrition Humaine, UMR 1019, Université Clermont Auvergne, INRAE, CRNH Auvergne, F-63000 Clermont-Ferrand, France., Briat A; Clermont Auvergne University, INSERM U 1240 Molecular Imaging and Theranostic Strategies, F-63000, Clermont-Ferrand, France., Guitton Y; Oniris, INRAE, Laberca, 44000 Nantes, France., Marchand F; Université Clermont Auvergne, Inserm U1107 NEURO-DOL, Pharmacologie Fondamentale et Clinique de la douleur, 28 Place Henri Dunant, BP 38, 63000 Clermont-Ferrand Cedex 01, France., Tournadre A; Unité de Nutrition Humaine, UMR 1019, Université Clermont Auvergne, INRAE, CRNH Auvergne, F-63000 Clermont-Ferrand, France; Service de Rhumatologie, Centre Hospitalier Universitaire Gabriel Montpied, F-63000 Clermont-Ferrand, France., Capel F; Unité de Nutrition Humaine, UMR 1019, Université Clermont Auvergne, INRAE, CRNH Auvergne, F-63000 Clermont-Ferrand, France. Electronic address: frederic.capel@inrae.fr.
Jazyk: angličtina
Zdroj: Life sciences [Life Sci] 2023 Aug 15; Vol. 327, pp. 121826. Date of Electronic Publication: 2023 Jun 01.
DOI: 10.1016/j.lfs.2023.121826
Abstrakt: Aims: Rheumatoid arthritis is an autoimmune disease which induces chronic inflammation and increases the risk for sarcopenia and metabolic abnormalities. Nutritional strategies using omega 3 polyunsaturated fatty acids could be proposed to alleviate inflammation and improve the maintenance of lean mass. Independently, pharmacological agents targeting key molecular regulators of the pathology such as TNF alpha could be proposed, but multiple therapies are frequently necessary increasing the risk for toxicity and adverse effects. The aim of the present study was to explore if the combination of an anti-TNF therapy (Etanercept) with dietary supplementation with omega 3 PUFA could prevent pain and metabolic effects of RA.
Materials and Methods: RA was induced using collagen-induced arthritis (CIA) in rats to explore of supplementation with docosahexaenoic acid, treatment with etanercept or their association could alleviate symptoms of RA (pain, dysmobility), sarcopenia and metabolic alterations.
Key Findings: We observed that Etanercept had major benefits on pain and RA scoring index. However, DHA could reduce the impact on body composition and metabolic alterations.
Significance: This study revealed for the first time that nutritional supplementation with omega 3 fatty acid could reduce some symptoms of rheumatoid arthritis and be an effective preventive treatment in patients who do not need pharmacological therapy, but no sign of synergy with an anti-TNF agent was observed.
Competing Interests: Declaration of competing interest The authors declare that there is no conflict of interest.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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