Alterations in pulmonary vasomotor modulators post aerobic exercise training in non-alcoholic fatty liver disease.

Autor: Cho J; Department of Cardiovascular Disease, Mayo Clinic, Rochester, MN, USA., Johnson BD; Department of Cardiovascular Disease, Mayo Clinic, Rochester, MN, USA., Watt KD; Department of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA., Niven AS; Department of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA., Shin J; Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic, Cleveland, OH, USA., Kim CH; Department of Cardiovascular Disease, Mayo Clinic, Rochester, MN, USA. Electronic address: Kim.Chulho@mayo.edu.
Jazyk: angličtina
Zdroj: Respiratory physiology & neurobiology [Respir Physiol Neurobiol] 2023 Aug; Vol. 314, pp. 104089. Date of Electronic Publication: 2023 Jun 01.
DOI: 10.1016/j.resp.2023.104089
Abstrakt: This study investigated the impact of exercise training on major pulmonary vasomotor mediators and receptors including endothelial nitric oxide synthase (eNOS) inducible NOS (iNOS), endothelin-1 (ET-1), ET-1 receptors A (ET A ) and-B (ET B ) in high-fat-high-carbohydrate (HFHC) induced non-alcoholic fatty liver disease (NAFLD). NAFLD increased iNOS, ET-1 and ET A (p < 0.05) , but not ET B (p > 0.05). Exercise attenuated iNOS, ET-1 and ET A (p < 0.05) ., but not ET B (p > 0.05) and eNOS (p > 0.05). Exercise training is beneficial for pulmonary vasculature in NAFLD.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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