Sleep is required to consolidate odor memory and remodel olfactory synapses.

Autor:	Chandra R; Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA., Farah F; Department of Biological Sciences, San José State University, San José, CA 95192, USA., Muñoz-Lobato F; Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA., Bokka A; Department of Biological Sciences, San José State University, San José, CA 95192, USA., Benedetti KL; Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA., Brueggemann C; Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA., Saifuddin MFA; Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA., Miller JM; Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA., Li J; Department of Biological Sciences, San José State University, San José, CA 95192, USA., Chang E; Department of Biological Sciences, San José State University, San José, CA 95192, USA., Varshney A; Department of Biological Sciences, San José State University, San José, CA 95192, USA., Jimenez V; Department of Biological Sciences, San José State University, San José, CA 95192, USA., Baradwaj A; Department of Biological Sciences, San José State University, San José, CA 95192, USA., Nassif C; Department of Biological Sciences, San José State University, San José, CA 95192, USA., Alladin S; Department of Biological Sciences, San José State University, San José, CA 95192, USA., Andersen K; Department of Biological Sciences, San José State University, San José, CA 95192, USA., Garcia AJ; Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA., Bi V; Department of Biological Sciences, San José State University, San José, CA 95192, USA., Nordquist SK; Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA., Dunn RL; Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA., Garcia V; Department of Biological Sciences, San José State University, San José, CA 95192, USA., Tokalenko K; Department of Biological Sciences, San José State University, San José, CA 95192, USA., Soohoo E; Department of Biological Sciences, San José State University, San José, CA 95192, USA., Briseno F; Department of Biological Sciences, San José State University, San José, CA 95192, USA., Kaur S; Department of Biological Sciences, San José State University, San José, CA 95192, USA., Harris M; Department of Biological Sciences, San José State University, San José, CA 95192, USA., Guillen H; Department of Biological Sciences, San José State University, San José, CA 95192, USA., Byrd D; Department of Biological Sciences, San José State University, San José, CA 95192, USA., Fung B; Department of Biological Sciences, San José State University, San José, CA 95192, USA., Bykov AE; Department of Biological Sciences, San José State University, San José, CA 95192, USA., Odisho E; Department of Biological Sciences, San José State University, San José, CA 95192, USA., Tsujimoto B; Department of Biological Sciences, San José State University, San José, CA 95192, USA., Tran A; Department of Biological Sciences, San José State University, San José, CA 95192, USA., Duong A; Department of Biological Sciences, San José State University, San José, CA 95192, USA., Daigle KC; Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA., Paisner R; Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA., Zuazo CE; Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA., Lin C; Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA., Asundi A; Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA., Churgin MA; Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Neuroscience, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA., Fang-Yen C; Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Neuroscience, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA., Bremer M; Department of Mathematics and Statistics, San José State University, San José, CA 95192, USA., Kato S; Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA., VanHoven MK; Department of Biological Sciences, San José State University, San José, CA 95192, USA. Electronic address: miri.vanhoven@sjsu.edu., L'Étoile ND; Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: noelle.letoile@ucsf.edu.
Jazyk:	angličtina
Zdroj:	Cell [Cell] 2023 Jun 22; Vol. 186 (13), pp. 2911-2928.e20. Date of Electronic Publication: 2023 Jun 02.
DOI:	10.1016/j.cell.2023.05.006
Abstrakt:	Animals with complex nervous systems demand sleep for memory consolidation and synaptic remodeling. Here, we show that, although the Caenorhabditis elegans nervous system has a limited number of neurons, sleep is necessary for both processes. In addition, it is unclear if, in any system, sleep collaborates with experience to alter synapses between specific neurons and whether this ultimately affects behavior. C. elegans neurons have defined connections and well-described contributions to behavior. We show that spaced odor-training and post-training sleep induce long-term memory. Memory consolidation, but not acquisition, requires a pair of interneurons, the AIYs, which play a role in odor-seeking behavior. In worms that consolidate memory, both sleep and odor conditioning are required to diminish inhibitory synaptic connections between the AWC chemosensory neurons and the AIYs. Thus, we demonstrate in a living organism that sleep is required for events immediately after training that drive memory consolidation and alter synaptic structures. Competing Interests: Declaration of interests The authors declare no competing interests. (Published by Elsevier Inc.)
Databáze:	MEDLINE
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