Concurrent Mycobacterium genavense infection and intestinal B-cell lymphoma in a pet rabbit (Oryctolaguscuniculus).

Autor: Monge E; Zoological Medicine Department, Université de Toulouse, ENVT, Chemin de Capelles, Toulouse, 31076, Occitanie, France; IHAP, Université de Toulouse, INRAe, ENVT - Toulouse, 31076, Occitanie, France. Electronic address: emma.monge@envt.fr., Garapin B; IHAP, Université de Toulouse, INRAe, ENVT - Toulouse, 31076, Occitanie, France; Department of Basic Sciences, Université de Toulouse, ENVT Chemin de Capelles, Toulouse, 31076, Occitanie, France., Lucas MN; Laboratoire d'Anatomie Pathologique Vétérinaire du Sud-Ouest, All. des Vitarelles, Toulouse, 31100, France., Gaide N; IHAP, Université de Toulouse, INRAe, ENVT - Toulouse, 31076, Occitanie, France; Department of Basic Sciences, Université de Toulouse, ENVT Chemin de Capelles, Toulouse, 31076, Occitanie, France., Le Loc'h G; Zoological Medicine Department, Université de Toulouse, ENVT, Chemin de Capelles, Toulouse, 31076, Occitanie, France; IHAP, Université de Toulouse, INRAe, ENVT - Toulouse, 31076, Occitanie, France., Donnelly TM; Exotic Animal Service, CHUVA, École Nationale Vétérinaire d'Alfort, Av. du Général de Gaulle, Maisons-Alfort, 94700, France., Delverdier M; Zoological Medicine Department, Université de Toulouse, ENVT, Chemin de Capelles, Toulouse, 31076, Occitanie, France; IHAP, Université de Toulouse, INRAe, ENVT - Toulouse, 31076, Occitanie, France.
Jazyk: angličtina
Zdroj: Journal of comparative pathology [J Comp Pathol] 2023 Jul; Vol. 204, pp. 1-6. Date of Electronic Publication: 2023 Jun 01.
DOI: 10.1016/j.jcpa.2023.04.007
Abstrakt: A 6-year-old male intact pet rabbit was evaluated for chronic weight loss. A large mass was detected by palpation in the mid-abdomen and ultrasound examination suggested a jejunal location. Explorative laparotomy revealed a nodular mass within the jejunal wall. Histological examination of a biopsy revealed mycobacterial granulomatous enteritis with an atypical lymphoblastic proliferation suggestive of lymphoma. Neoplastic lymphocytes were immunopositive for Pax-5 but negative for CD3, which is diagnostic of a B-cell neoplasm. Numerous acid-fast bacteria were seen within histiocytes and identified by polymerase chain reaction as Mycobacterium genavense, which is a non-tuberculous and opportunistic mycobacterium with zoonotic potential. To the best of our knowledge, this is the first documented case of a concurrent B-cell lymphoma and M. genavense infection in a rabbit. Concomitant mycobacteriosis and lymphoma have been rarely described in animals and the coexistence of neoplasia and mycobacterial infection within the jejunum suggests a potential pathogenetic association. Interestingly, the rabbit owner worked in an anti-tuberculosis clinic, and an anthropic origin of the mycobacterial infection could not be excluded.
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Databáze: MEDLINE
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