Transcriptomics, metabolomics, and in-silico drug predictions for liver damage in young and aged burn victims.

Autor: Malachowska B; Department of Radiation Oncology, Albert Einstein College of Medicine, Bronx, NY, 10461, USA., Yang WL; Department of Radiation Oncology, Albert Einstein College of Medicine, Bronx, NY, 10461, USA., Qualman A; Department of Surgery; Division of G.I., Trauma, and Endocrine Surgery, University of Colorado, Aurora, CO, 80045, USA., Muro I; Department of Surgery; Division of G.I., Trauma, and Endocrine Surgery, University of Colorado, Aurora, CO, 80045, USA., Boe DM; Department of Surgery; Division of G.I., Trauma, and Endocrine Surgery, University of Colorado, Aurora, CO, 80045, USA.; Graduate Program in Immunology, University of Colorado, Aurora, CO, 80045, USA., Lampe JN; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy, University of Colorado, Aurora, CO, 80045, USA., Kovacs EJ; Department of Surgery; Division of G.I., Trauma, and Endocrine Surgery, University of Colorado, Aurora, CO, 80045, USA.; Graduate Program in Immunology, University of Colorado, Aurora, CO, 80045, USA.; Molecular Biology Program, University of Colorado, Aurora, CO, 80045, USA., Idrovo JP; Department of Surgery; Division of G.I., Trauma, and Endocrine Surgery, University of Colorado, Aurora, CO, 80045, USA. juan.idrovo@cuanschutz.edu.
Jazyk: angličtina
Zdroj: Communications biology [Commun Biol] 2023 Jun 02; Vol. 6 (1), pp. 597. Date of Electronic Publication: 2023 Jun 02.
DOI: 10.1038/s42003-023-04964-2
Abstrakt: Burn induces a systemic response affecting multiple organs, including the liver. Since the liver plays a critical role in metabolic, inflammatory, and immune events, a patient with impaired liver often exhibits poor outcomes. The mortality rate after burns in the elderly population is higher than in any other age group, and studies show that the liver of aged animals is more susceptible to injury after burns. Understanding the aged-specific liver response to burns is fundamental to improving health care. Furthermore, no liver-specific therapy exists to treat burn-induced liver damage highlighting a critical gap in burn injury therapeutics. In this study, we analyzed transcriptomics and metabolomics data from the liver of young and aged mice to identify mechanistic pathways and in-silico predict therapeutic targets to prevent or reverse burn-induced liver damage. Our study highlights pathway interactions and master regulators that underlie the differential liver response to burn injury in young and aged animals.
(© 2023. The Author(s).)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje