Developing Phage Therapy That Overcomes the Evolution of Bacterial Resistance.
| Autor: | Oromí-Bosch A; Felix Biotechnology Inc., San Francisco, California, USA., Antani JD; Department of Ecology and Evolutionary Biology, Center for Phage Biology & Therapy, and Quantitative Biology Institute, Yale University, New Haven, Connecticut, USA; email: paul.turner@yale.edu., Turner PE; Department of Ecology and Evolutionary Biology, Center for Phage Biology & Therapy, and Quantitative Biology Institute, Yale University, New Haven, Connecticut, USA; email: paul.turner@yale.edu.; Program in Microbiology, Yale School of Medicine, New Haven, Connecticut, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Annual review of virology [Annu Rev Virol] 2023 Sep 29; Vol. 10 (1), pp. 503-524. Date of Electronic Publication: 2023 Jun 02. |
| DOI: | 10.1146/annurev-virology-012423-110530 |
| Abstrakt: | The global rise of antibiotic resistance in bacterial pathogens and the waning efficacy of antibiotics urge consideration of alternative antimicrobial strategies. Phage therapy is a classic approach where bacteriophages (bacteria-specific viruses) are used against bacterial infections, with many recent successes in personalized medicine treatment of intractable infections. However, a perpetual challenge for developing generalized phage therapy is the expectation that viruses will exert selection for target bacteria to deploy defenses against virus attack, causing evolution of phage resistance during patient treatment. Here we review the two main complementary strategies for mitigating bacterial resistance in phage therapy: minimizing the ability for bacterial populations to evolve phage resistance and driving (steering) evolution of phage-resistant bacteria toward clinically favorable outcomes. We discuss future research directions that might further address the phage-resistance problem, to foster widespread development and deployment of therapeutic phage strategies that outsmart evolved bacterial resistance in clinical settings. |
| Databáze: | MEDLINE |
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