Parental experience is linked with lower vasopressin receptor 1a binding and decreased postpartum androgens in titi monkeys.

Autor: Baxter A; Department of Psychology, University of California, Davis, Davis, California, USA.; California National Primate Research Center, Davis, California, USA., Karaskiewicz CL; Department of Psychology, University of California, Davis, Davis, California, USA.; California National Primate Research Center, Davis, California, USA., Campbell LA; California National Primate Research Center, Davis, California, USA.; Department of Animal Biology, University of California, Davis, Davis, California, USA., Kinnally EL; Department of Psychology, University of California, Davis, Davis, California, USA.; California National Primate Research Center, Davis, California, USA., Ferrer E; Department of Psychology, University of California, Davis, Davis, California, USA., Seelke AHM; Department of Psychology, University of California, Davis, Davis, California, USA.; California National Primate Research Center, Davis, California, USA., Freeman SM; California National Primate Research Center, Davis, California, USA.; Department of Biology, Utah State University, Logan, Utah, USA., Bales KL; Department of Psychology, University of California, Davis, Davis, California, USA.; California National Primate Research Center, Davis, California, USA.; Department of Neurobiology, Physiology, and Behavior, University of California, Davis, Davis, California, USA.
Jazyk: angličtina
Zdroj: Journal of neuroendocrinology [J Neuroendocrinol] 2023 Jul; Vol. 35 (7), pp. e13304. Date of Electronic Publication: 2023 Jun 02.
DOI: 10.1111/jne.13304
Abstrakt: Parenting induces many neurological and behavioral changes that enable parents to rear offspring. Vasopressin plays an important role in this process via its effects on cognition, affect, and neuroplasticity, and in some cases, via interactions with decreased parental androgens. Thus far, the role of these hormones has been primarily studied in rodents. To address this gap, we explored vasopressin receptors and androgens in titi monkeys, a pair-bonding and biparental primate species. In Studies 1 and 2, we used receptor autoradiography to correlate arginine vasopressin receptor 1a (AVPR1a) binding in the hippocampus (Study 1, n = 10) and the rest of the forebrain (Study 2, n = 23) with parental status, parental experience, parity, infant carrying, and pair affiliation. We found that parents exhibited lower AVPR1a binding than non-parents throughout most brain regions assessed, with especially strong effects in the hippocampus (β = -.61), superior colliculus (β = -.88), lateral septum (β = -.35), and medial preoptic area (β = -.29). The other measures of parental experience also tended to be negatively associated with AVPR1a binding across different brain regions. In Study 3 (n = 44), we compared pre- and postpartum urinary androgen levels in parents and non-parents and found that mothers exhibited a sustained androgen decrease across 3-4 months postpartum (relative to 3 months prepartum; β ranged from -.72 to -.62 for different comparisons). For males, we found that multiparous fathers exhibited decreased androgen levels at 1-2 weeks postpartum (β = -.25) and at 3-4 months postpartum (β = -.40) compared to the prepartum, indicating both immediate and long-term reductions with subsequent paternal experience. Together, the results of this study suggest that decreases in AVPR1a binding and circulating androgens are associated with parental behavior and physiology in titi monkeys.
(© 2023 The Authors. Journal of Neuroendocrinology published by John Wiley & Sons Ltd on behalf of British Society for Neuroendocrinology.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje