| Autor: |
Nobin H; Department of Pathology, Tomo Riba Institute of Health and Medical Sciences, Naharlagun, Arunachal Pradesh, India., Kothapalli J; Department of Anatomy, Tomo Riba Institute of Health and Medical Sciences, Naharlagun, Arunachal Pradesh, India., Jini M; Department of Surgery, Tomo Riba Institute of Health and Medical Sciences, Naharlagun, Arunachal Pradesh, India., Chauhan S; Government of Arunachal Pradesh, Itanagar, Arunachal Pradesh, India., Tato Y; Arunachal Pradesh Health Service, Directorate of Health Service, Naharlagun, Arunachal Pradesh, India., Munikumar M; Clinical Division, ICMR-National Institute of Nutrition, Hyderabad, Telangana, India. |
| Jazyk: |
angličtina |
| Zdroj: |
Maedica [Maedica (Bucur)] 2023 Mar; Vol. 18 (1), pp. 88-95. |
| DOI: |
10.26574/maedica.2023.18.1.88 |
| Abstrakt: |
Objective: The assessment of novel coronavirus disease 2019 (COVID-19) antibodies is essential to understand the transmission dynamics of contagious disease. The proportion of the population who developed antibodies against the COVID-19 disease can be estimated through population-based serosurveys. This population based cross sectional serosurvey was designed to assess the seroprevalence of IgG and IgM antibodies of COVID-19 infection. Material and methods: A population based cross sectional serosurvey included 1031 residents of Itanagar Capital Complex region (ICR), Arunachal Pradesh, India, aged above five years. Anti-SARS-CoV-2 specific IgG and IgM antibody levels were analyzed by chemiluminescence immunoassay based serological tests. Results: The overall seropositivity for SARS-CoV-2 IgG and IgM was 92.24% and 7.7%, respectively. The seropositivity of IgG and IgM was 97.68% and 2.32%, respectively, in subjects fully vaccinated with two doses, 97.22% and 13.88%, respectively, in those vaccinated with the first dose, and 80% and 11.33%, respectively, in non-vaccinated participants. In contrast to indigenous tribal participants (IgG 90.55% and IgM 8.88%), seroprevalence was high in non-tribal subjects (IgG 94.72% and IgM 6.84%). Age, ethnicity, and area showed a positive correlation, while vaccination status exhibited a negative correlation with IgG levels (Pearson's coefficient -0.535). Conclusions: This first monocentric serosurvey following the high rate of infection with Delta variant in ICR found a high seropositivity for IgG. Further state level serosurveys are needed to assess the infection status, immunological response and associated comorbidities of COVID-19 infection. Periodic vaccination campaigns and early administration of booster doses to the general public might be beneficial in preserving immunity and prevent illness. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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