Expression profile of interleukin-6, 4-hydroxy-2-nonenal, and hypoxia-inducible factor 1-α in women with breast cancer and their association with clinicopathological parameters.
Autor: | Yahia S; Biology of Development and Differentiation Laboratory, Ahmed Ben Bella Oran 1 University, Oran, Algeria., Tahari Z; Biology of Development and Differentiation Laboratory, Ahmed Ben Bella Oran 1 University, Oran, Algeria.; Department of the Living and Environment, University of Sciences and Technology of Oran, Mohammed-Boudiaf, Oran, Algeria., Medjdoub A; Biology of Development and Differentiation Laboratory, Ahmed Ben Bella Oran 1 University, Oran, Algeria.; Department of the Living and Environment, University of Sciences and Technology of Oran, Mohammed-Boudiaf, Oran, Algeria., Tahari FZ; Biology of Development and Differentiation Laboratory, Ahmed Ben Bella Oran 1 University, Oran, Algeria.; University Ain Temouchent Belhadj Bouchaib, Ain Temouchent, Algeria., Bessaih N; Department of Medical Oncology, University Hospital Establishment of Oran, Faculty of Medicine, Ahmed Ben Bella Oran 1 University, Oran, Algeria., Messatfa M; Faculty of Medicine, Abdelhamid Ben Badis University Mostaganem, Mostaganem, Algeria.; Immunology Laboratory, Pasteur Institute of Oran, Oran, Algeria., Deblaoui F; Department of Gynaecology and Obstetrics, University Hospital Establishment of Oran, Oran, Algeria., Raiah M; Department of Epidemiology and Preventive Medicine, University Hospital of Oran, Faculty of Medicine, Ahmed Ben Bella Oran 1 University, Oran, Algeria., Ouldcadi H; Biology of Development and Differentiation Laboratory, Ahmed Ben Bella Oran 1 University, Oran, Algeria., Seddiki S; Biology of Development and Differentiation Laboratory, Ahmed Ben Bella Oran 1 University, Oran, Algeria., Sahraoui T; Biology of Development and Differentiation Laboratory, Ahmed Ben Bella Oran 1 University, Oran, Algeria. |
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Jazyk: | angličtina |
Zdroj: | Contemporary oncology (Poznan, Poland) [Contemp Oncol (Pozn)] 2023; Vol. 27 (1), pp. 14-21. Date of Electronic Publication: 2023 Apr 27. |
DOI: | 10.5114/wo.2023.127199 |
Abstrakt: | Introduction: Breast cancer (BC) is the most common malignancy in women worldwide, representing a major public health burden. Therefore, there is a need to identify circulating biomarkers for the early detection of BC and to facilitate the diagnosis. Interleukin-6 (IL-6), 4-hydroxy-2-nonenal (4-HNE), and hypoxia-inducible factor 1-α (HIF-1α) are biomarkers involved in the initiation and progression of this disease. The aim of this study was to evaluate the concentrations of these molecules and to find a possible correlation with the clinicopathological parameters of patients with BC from western Algeria. Material and Methods: We evaluated the serum levels of IL-6, 4-HNE, and HIF-1α by ELISA technique and compare them in different age groups and BC molecular subtypes, and then correlated them with clinicopathological parameters. Results: Our study revealed a significant increase in 4-HNE (p < 0.05), and a negative correlation (p < 0.05) was found between IL-6 serum levels and lymph node count, but not (p > 0.05) between 4-HNE, HIF-1α and lymph node count. No significant correlation (p > 0.05) was found between IL-6, 4-HNE, HIF-1α , and Scarff-Bloom-Richardson grade. Furthermore, there was no significant difference ( p > 0.05) in serum levels of IL-6, 4-HNE, and HIF-1α in the different age groups and molecular subtypes of BC. Conclusions: The data obtained show that the presence of lipid peroxidation (4-HNE) is a marker of oxidative stress, and that IL-6 is a good prognostic factor due to its negative effect on the number of lymph nodes. Furthermore, age and BC molecular subtypes do not influence the serum concentrations of IL-6,4-HNE, and HIF-1α. Competing Interests: The authors declare no conflict of interest. (Copyright © 2023 Termedia.) |
Databáze: | MEDLINE |
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