Age But Not Menopausal Status Is Linked to Lower Resting Energy Expenditure.

Autor:	Karppinen JE; Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland., Wiklund P; Huawei Helsinki Research Center, Huawei Technologies Oy (Finland) Co. Ltd, Helsinki, Finland., Ihalainen JK; Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland., Juppi HK; Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland.; Gerontology Research Center, University of Jyväskylä, Jyväskylä, Finland., Isola V; Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland., Hyvärinen M; Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland.; Gerontology Research Center, University of Jyväskylä, Jyväskylä, Finland., Ahokas EK; Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland., Kujala UM; Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland., Laukkanen J; Central Finland Health Care District, Jyväskylä, Finland.; Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland., Hulmi JJ; Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland., Ahtiainen JP; Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland., Cheng S; Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland.; Exercise Translational Medicine Centre, Shanghai Jiao Tong University, Shanghai, China., Laakkonen EK; Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland.; Gerontology Research Center, University of Jyväskylä, Jyväskylä, Finland.
Jazyk:	angličtina
Zdroj:	The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2023 Oct 18; Vol. 108 (11), pp. 2789-2797.
DOI:	10.1210/clinem/dgad321
Abstrakt:	Context: It remains uncertain whether aging before late adulthood and menopause are associated with fat-free mass and fat mass-adjusted resting energy expenditure (REEadj). Objectives: We investigated whether REEadj differs between middle-aged and younger women and between middle-aged women with different menopausal statuses. We repeated the age group comparison between middle-aged mothers and their daughters to partially control for genotype. We also explored whether serum estradiol and FSH concentrations explain REEadj in midlife. Methods: We divided 120 women, including 16 mother-daughter pairs, into age groups; group I (n = 26) consisted of participants aged 17 to 21, group II (n = 35) of those aged 22 to 38, and group III (n = 59) of those aged 41 to 58 years. The women in group III were further categorized as pre- or perimenopausal (n = 19), postmenopausal (n = 30), or postmenopausal hormone therapy users (n = 10). REE was assessed using indirect calorimetry, body composition using dual-energy X-ray absorptiometry, and hormones using immunoassays. Results: The REEadj of group I was 126 kcal/day [95% confidence interval (CI): 93-160] higher than that of group III, and the REEadj of group II was 88 kcal/day (95% CI: 49-127) higher. Furthermore, daughters had a 100 kcal/day (95% CI: 63-138 kcal/day) higher REEadj than their middle-aged mothers (all P < .001). In group III, REEadj was not lower in postmenopausal women and did not vary by sex hormone concentrations. Conclusions: We demonstrated that REEadj declines with age in women before late adulthood, also when controlling partially for genetic background, and that menopause may not contribute to this decline. (© The Author(s) 2023. Published by Oxford University Press on behalf of the Endocrine Society.)
Databáze:	MEDLINE
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