| Autor: |
He XQ; Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy and Clinical Skills Comprehensive Training Center, The First Affiliated Hospital, Jinan University, Guangzhou, China., Li HB; National Key Laboratory on Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture, Kanion Pharmaceutical Co. Ltd., Lianyungang, China., Li T; Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy and Clinical Skills Comprehensive Training Center, The First Affiliated Hospital, Jinan University, Guangzhou, China., Chen XY; Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy and Clinical Skills Comprehensive Training Center, The First Affiliated Hospital, Jinan University, Guangzhou, China., Wang ZZ; National Key Laboratory on Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture, Kanion Pharmaceutical Co. Ltd., Lianyungang, China., Yao XS; Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy and Clinical Skills Comprehensive Training Center, The First Affiliated Hospital, Jinan University, Guangzhou, China., Xiao W; National Key Laboratory on Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture, Kanion Pharmaceutical Co. Ltd., Lianyungang, China., Yu Y; Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy and Clinical Skills Comprehensive Training Center, The First Affiliated Hospital, Jinan University, Guangzhou, China. |
| Abstrakt: |
One undescribed benzofuran derivative (illiciumphenolicacid A, 1 ) and one new phenolic glycoside (illiciumphenolicacid B, 2 ), together with six known compounds ( 3-8 ) were isolated from the leaves of Illicium dunnianum Tutcher. Their structures were elucidated by detailed spectroscopic data (UV, IR, HR-ESI-MS, 1D and 2D NMR). In addition, we determined the α -glucosidase inhibitory activity of the isolates in vitro using spectrophotometric methods. Compared with the positive control acarbose (IC 50 306.2 ± 4.1 μ M), compounds 1-8 were shown to be moderate potential α -glucosidase inhibitory activity with IC 50 values in the range 380-655 μ M. |
