Modulation of Visual Contrast Sensitivity with tRNS across the Visual System, Evidence from Stimulation and Simulation.

Autor:	Potok W; Neural Control of Movement Lab, Department of Health Sciences and Technology, ETH Zürich, Zurich 8093, Switzerland weronika.potok@hest.ethz.ch nicole.wenderoth@hest.ethz.ch.; Neuroscience Center Zurich (ZNZ), University of Zurich, ETH Zurich, University and Balgrist Hospital Zurich, Zurich 8057, Switzerland., Post A; Neural Control of Movement Lab, Department of Health Sciences and Technology, ETH Zürich, Zurich 8093, Switzerland., Beliaeva V; Decision Neuroscience Lab, Department of Health Sciences and Technology, ETH Zürich, Zurich 8057, Switzerland., Bächinger M; Neural Control of Movement Lab, Department of Health Sciences and Technology, ETH Zürich, Zurich 8093, Switzerland.; Neuroscience Center Zurich (ZNZ), University of Zurich, ETH Zurich, University and Balgrist Hospital Zurich, Zurich 8057, Switzerland., Cassarà AM; Foundation for Research on Information Technologies in Society (IT'IS), Zurich 8004, Switzerland., Neufeld E; Foundation for Research on Information Technologies in Society (IT'IS), Zurich 8004, Switzerland., Polania R; Neuroscience Center Zurich (ZNZ), University of Zurich, ETH Zurich, University and Balgrist Hospital Zurich, Zurich 8057, Switzerland.; Decision Neuroscience Lab, Department of Health Sciences and Technology, ETH Zürich, Zurich 8057, Switzerland., Kiper D; Life Science Zurich Learning Center, Zurich 8057, Switzerland., Wenderoth N; Neural Control of Movement Lab, Department of Health Sciences and Technology, ETH Zürich, Zurich 8093, Switzerland weronika.potok@hest.ethz.ch nicole.wenderoth@hest.ethz.ch.; Neuroscience Center Zurich (ZNZ), University of Zurich, ETH Zurich, University and Balgrist Hospital Zurich, Zurich 8057, Switzerland.; Future Health Technologies, Singapore-ETH Centre, Campus for Research Excellence And Technological Enterprise (CREATE), 138602, Singapore.
Jazyk:	angličtina
Zdroj:	ENeuro [eNeuro] 2023 Jun 16; Vol. 10 (6). Date of Electronic Publication: 2023 Jun 16 (Print Publication: 2023).
DOI:	10.1523/ENEURO.0177-22.2023
Abstrakt:	Transcranial random noise stimulation (tRNS) has been shown to significantly improve visual perception. Previous studies demonstrated that tRNS delivered over cortical areas acutely enhances visual contrast detection of weak stimuli. However, it is currently unknown whether tRNS-induced signal enhancement could be achieved within different neural substrates along the retino-cortical pathway. In three experimental sessions, we tested whether tRNS applied to the primary visual cortex (V1) and/or to the retina improves visual contrast detection. We first measured visual contrast detection threshold (VCT; N  = 24, 16 females) during tRNS delivery separately over V1 and over the retina, determined the optimal tRNS intensities for each individual (ind-tRNS), and retested the effects of ind-tRNS within the sessions. We further investigated whether we could reproduce the ind-tRNS-induced modulation on a different session ( N  = 19, 14 females). Finally, we tested whether the simultaneous application of ind-tRNS to the retina and V1 causes additive effects. Moreover, we present detailed simulations of the induced electric field across the visual system. We found that at the group level tRNS decreases VCT compared with baseline when delivered to the V1. Beneficial effects of ind-tRNS could be replicated when retested within the same experimental session but not when retested in a separate session. Applying tRNS to the retina did not cause a systematic reduction of VCT, regardless of whether the individually optimized intensity was considered or not. We also did not observe consistent additive effects of V1 and retina stimulation. Our findings demonstrate significant tRNS-induced modulation of visual contrast processing in V1 but not in the retina. Competing Interests: The authors declare no competing financial interests. (Copyright © 2023 Potok et al.)
Databáze:	MEDLINE
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