Genetic Ancestry, Race, and Severity of Acutely Decompensated Cirrhosis in Latin America.

Autor:	Farias AQ; The Department of Gastroenterology, Hospital das Clínicas, University of São Paulo School of Medicine, São Paulo, Brazil., Curto Vilalta A; European Foundation for the Study of Chronic Liver Failure, Barcelona, Spain., Momoyo Zitelli P; The Department of Gastroenterology, Hospital das Clínicas, University of São Paulo School of Medicine, São Paulo, Brazil., Pereira G; Gastroenterology and Hepatology Unit, Bonsucesso Federal Hospital, Ministry of Health, Rio de Janeiro, Brazil; Estácio de Sá University, School of Medicine, Rio de Janeiro, Brazil., Goncalves LL; Gastroenterology and Hepatology Unit, Hospital Universitário Cassiano Antônio Moraes, Universidade Federal do Espírito Santo, Vitória, Brazil., Torre A; Departamento de Gastroenterología, Instituto Nacional de Ciencias Médicas y Nutrición 'Salvador Zubirán,' Mexico City, Mexico., Diaz JM; European Foundation for the Study of Chronic Liver Failure, Barcelona, Spain; Liver Unit and Department of Research, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina., Gadano AC; Liver Unit and Department of Research, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina., Mattos AZ; Federal University of Health Sciences of Porto Alegre, and Gastroenterology and Hepatology Unit, Irmandade Santa Casa de Misericórdia de Porto Alegre, Porto Alegre, Brazil., Mendes LSC; Hospital de Base do Distrito Federal, Brasilia, Brazil., Alvares-da-Silva MR; Gastrointestinal and Liver Unit, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil., Bittencourt PL; Hospital Português da Bahia, Salvador, Brazil., Benitez C; Departamento de Gastroenterología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile., Couto CA; Instituto Alfa de Gastroenterologia, Hospital das Clínicas da Universidade Federal de Minas Gerais, Belo Horizonte, Brazil; Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Mendizabal M; Unidad de Hígado y Trasplante Hepático, Hospital Universitario Austral, Pilar, Buenos Aires, Argentina., Toledo CL; Universidad Austral de Chile, Hospital Valdivia, Valdivia, Chile., Mazo DFC; Division of Gastroenterology, University of Campinas, Campinas, Brazil., Castillo Barradas M; Servicio de Gastroenterología y Hepatología, Hospital de Especialidades Centro Médico Nacional La Raza Instituto Mexicano del Seguro Social, Mexico City, Mexico., Uson Raposo EM; European Foundation for the Study of Chronic Liver Failure, Barcelona, Spain., Padilla-Machaca PM; Hospital Nacional Guillermo Almenara, and Universidad Nacional de San Marcos, Lima, Peru., Zarela Lozano Miranda A; Unidad de Hígado, Hospital Nacional Arzobispo Loayza, Lima, Peru., Malé-Velázquez R; Instituto de Salud Digestiva y Hepática, Guadalajara, Mexico., Castro Lyra A; Hospital Universtário Professor Edgard Santos, Salvador, Brazil; Hospital São Rafael, Salvador, Brazil., Dávalos-Moscol MB; Hospital Nacional Edgardo Rebagliati Martins-EsSalud, Lima, Peru., Pérez Hernández JL; Clínica de hígado, Hospital General de México 'Dr. Eduardo Liceaga,' Mexico City, Mexico., Ximenes RO; Serviço de Gastroenterologia e Hepatologia, Hospital das Clínicas da Universidade Federal de Goiás, Goiânia, Brazil., Faria Silva G; Faculdade de Medicina de Botucatu, Botucatu, Brazil., Beltrán-Galvis OA; Grupo Gastro-Hepatología y Trasplante Fundación Cardioinfantil LaCardio, Medellín, Colombia., González Huezo MS; Departamento de Gastroenterología, Centro Médico Instituto de Seguridad Social del Estado de México y Municipios, Metepec, Mexico., Bessone F; Hospital Provincial del Centenario, Universidad Nacional de Rosario, Rosario, Argentina., Rocha TDS; Hospital Universitário Walter Cantídio, Fortaleza, Brazil., Fassio E; Sección Hígado, Vías Biliares y Páncreas del Servicio de Gastroenterología, Hospital Nacional Profesor Alejandro, Buenos Aires, Argentina., Terra C; Serviço de Gastroenterologia, Unidade de Hepatologia, Hospital Universitario Pedro Ernesto, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil., Marín JI; Bogotá and Hospital Pablo Tobón Uribe, Medellín, Colombia., Sierra Casas P; European Foundation for the Study of Chronic Liver Failure, Barcelona, Spain., de la Peña-Ramirez C; European Foundation for the Study of Chronic Liver Failure, Barcelona, Spain., Aguilar Parera F; European Foundation for the Study of Chronic Liver Failure, Barcelona, Spain., Fernandes F; Gastroenterology and Hepatology Unit, Bonsucesso Federal Hospital, Ministry of Health, Rio de Janeiro, Brazil., da Penha Zago-Gomes M; Gastroenterology and Hepatology Unit, Hospital Universitário Cassiano Antônio Moraes, Universidade Federal do Espírito Santo, Vitória, Brazil., Méndez-Guerrero O; Departamento de Gastroenterología, Instituto Nacional de Ciencias Médicas y Nutrición 'Salvador Zubirán,' Mexico City, Mexico., Marciano S; Liver Unit and Department of Research, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina., Mattos AA; Federal University of Health Sciences of Porto Alegre, and Gastroenterology and Hepatology Unit, Irmandade Santa Casa de Misericórdia de Porto Alegre, Porto Alegre, Brazil., Oliveira JC; Hospital de Base do Distrito Federal, Brasilia, Brazil., Guerreiro GTS; Gastrointestinal and Liver Unit, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil., Codes L; Hospital Português da Bahia, Salvador, Brazil., Arrese M; Departamento de Gastroenterología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; Centro de Envejecimiento y Regeneracion, Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Católica de Chile, Santiago, Chile., Nardelli MJ; Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Silva MO; Unidad de Hígado y Trasplante Hepático, Hospital Universitario Austral, Pilar, Buenos Aires, Argentina., Palma-Fernandez R; Universidad Austral de Chile, Hospital Valdivia, Valdivia, Chile., Alcantara C; Gastroenterology and Hepatology Unit, Bonsucesso Federal Hospital, Ministry of Health, Rio de Janeiro, Brazil., Sánchez Garrido C; European Foundation for the Study of Chronic Liver Failure, Barcelona, Spain., Trebicka J; Medizinische Klinik B (Gastroenterologie, Hepatologie, Endokrinologie, Klinische Infektiologie), Münster, Germany., Gustot T; European Foundation for the Study of Chronic Liver Failure, Barcelona, Spain; Department of Gastroenterology and Hepato-Pancreatology, Cliniques Universitaires de Bruxelles Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium., Fernández J; European Foundation for the Study of Chronic Liver Failure, Barcelona, Spain; Hospital Clínic Instituto de Investigaciones Biomédicas August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain., Clària J; European Foundation for the Study of Chronic Liver Failure, Barcelona, Spain; Hospital Clínic Instituto de Investigaciones Biomédicas August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain; Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas Barcelona, Spain., Jalan R; European Foundation for the Study of Chronic Liver Failure, Barcelona, Spain; Liver Failure Group, Institute for Liver Disease Health, University College London, Royal Free Hospital, London, United Kingdom., Angeli P; European Foundation for the Study of Chronic Liver Failure, Barcelona, Spain; Unit of Internal Medicine and Hepatology, Department of Medicine, University of Padova, Padova, Italy., Arroyo V; European Foundation for the Study of Chronic Liver Failure, Barcelona, Spain., Moreau R; European Foundation for the Study of Chronic Liver Failure, Barcelona, Spain; Institut National de la Santé et de la Recherche Médicale, Université Paris Cité, Centre de Recherche sur l'Inflammation, Paris, France; Assistance Publique-Hôpitaux de Paris, Hôpital Beaujon, Service d'Hépatologie, Clichy, France. Electronic address: richard.moreau@inserm.fr., Carrilho FJ; The Department of Gastroenterology, Hospital das Clínicas, University of São Paulo School of Medicine, São Paulo, Brazil.
Jazyk:	angličtina
Zdroj:	Gastroenterology [Gastroenterology] 2023 Sep; Vol. 165 (3), pp. 696-716. Date of Electronic Publication: 2023 May 30.
DOI:	10.1053/j.gastro.2023.05.033
Abstrakt:	Background & Aims: Genetic ancestry or racial differences in health outcomes exist in diseases associated with systemic inflammation (eg, COVID-19). This study aimed to investigate the association of genetic ancestry and race with acute-on-chronic liver failure (ACLF), which is characterized by acute systemic inflammation, multi-organ failure, and high risk of short-term death. Methods: This prospective cohort study analyzed a comprehensive set of data, including genetic ancestry and race among several others, in 1274 patients with acutely decompensated cirrhosis who were nonelectively admitted to 44 hospitals from 7 Latin American countries. Results: Three hundred ninety-five patients (31.0%) had ACLF of any grade at enrollment. Patients with ACLF had a higher median percentage of Native American genetic ancestry and lower median percentage of European ancestry than patients without ACLF (22.6% vs 12.9% and 53.4% vs 59.6%, respectively). The median percentage of African genetic ancestry was low among patients with ACLF and among those without ACLF. In terms of race, a higher percentage of patients with ACLF than patients without ACLF were Native American and a lower percentage of patients with ACLF than patients without ACLF were European American or African American. In multivariable analyses that adjusted for differences in sociodemographic and clinical characteristics, the odds ratio for ACLF at enrollment was 1.08 (95% CI, 1.03-1.13) with Native American genetic ancestry and 2.57 (95% CI, 1.84-3.58) for Native American race vs European American race CONCLUSIONS: In a large cohort of Latin American patients with acutely decompensated cirrhosis, increasing percentages of Native American ancestry and Native American race were factors independently associated with ACLF at enrollment. (Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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