Drug delivery strategies for antibiofilm therapy.

Autor: Choi V; Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Oxford, UK., Rohn JL; Department of Renal Medicine, Centre for Urological Biology, Division of Medicine, University College London, London, UK., Stoodley P; Departments of Microbial Infection and Immunity, Microbiology and Orthopaedics, The Ohio State University, Columbus, OH, USA.; Department of Mechanical Engineering, National Centre for Advanced Tribology at Southampton (nCATS) and National Biofilm Innovation Centre (NBIC), University of Southampton, Southampton, UK., Carugo D; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Stride E; Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Oxford, UK. eleanor.stride@eng.ox.ac.uk.; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK. eleanor.stride@eng.ox.ac.uk.
Jazyk: angličtina
Zdroj: Nature reviews. Microbiology [Nat Rev Microbiol] 2023 Sep; Vol. 21 (9), pp. 555-572. Date of Electronic Publication: 2023 May 31.
DOI: 10.1038/s41579-023-00905-2
Abstrakt: Although new antibiofilm agents have been developed to prevent and eliminate pathogenic biofilms, their widespread clinical use is hindered by poor biocompatibility and bioavailability, unspecific interactions and insufficient local concentrations. The development of innovative drug delivery strategies can facilitate penetration of antimicrobials through biofilms, promote drug dispersal and synergistic bactericidal effects, and provide novel paradigms for clinical application. In this Review, we discuss the potential benefits of such emerging techniques for improving the clinical efficacy of antibiofilm agents, as well as highlighting the existing limitations and future prospects for these therapies in the clinic.
(© 2023. Springer Nature Limited.)
Databáze: MEDLINE
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